Structure of the Integrator arm module containing INTS10/13/14 subunits
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9eoc
Q-score: 0.458
Razew M, Fraudeau A, Pfleiderer MM, Linares R, Galej WP
Mol Cell (2024) 84 pp. 2542- [ Pubmed: 38823386 DOI: doi:10.1016/j.molcel.2024.05.009 ]
- Integrator complex subunit 14 (57 kDa, Protein from Homo sapiens)
- Integrator complex subunit 13 (80 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Integrator complex subunit 10 (82 kDa, Protein from Homo sapiens)
- Ints10/13/14 complex of the integrator's arm module (Complex from Homo sapiens)
Structure of the human INTS5/8/10/15 subcomplex
Resolution: 7.7 Å
EM Method: Single-particle
Fitted PDBs: 9eof
Q-score: 0.045
Razew M, Fraudeau A, Pfleiderer MM, Linares R, Galej WP
Mol Cell (2024) 84 pp. 2542- [ Pubmed: 38823386 DOI: doi:10.1016/j.molcel.2024.05.009 ]
- Integrator complex subunit 10 (82 kDa, Protein from Homo sapiens)
- Structure of ints5/8/10/15 subcomplex (Complex from Homo sapiens)
- Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
- Integrator complex subunit 15 (50 kDa, Protein from Homo sapiens)
Structure of the Integrator arm module containing INTS10/13/14/15 subunits (state 2)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 9ep1
Q-score: 0.308
Razew M, Fraudeau A, Pfleiderer MM, Linares R, Galej WP
Mol Cell (2024) 84 pp. 2542- [ Pubmed: 38823386 DOI: doi:10.1016/j.molcel.2024.05.009 ]
- Integrator complex subunit 14 (57 kDa, Protein from Homo sapiens)
- Integrator complex subunit 13 (63 kDa, Protein from Homo sapiens)
- Integrator complex subunit 10 (82 kDa, Protein from Homo sapiens)
- Structure of the integrator arm module containing ints10/13/14/15 subunits (state 2) (270 kDa, Complex from Homo sapiens)
- Integrator complex subunit 15 (43 kDa, Protein from Homo sapiens)
Structure of Integrator subcomplex INTS5/8/15
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ep4
Q-score: 0.244
Razew M, Fraudeau A, Pfleiderer MM, Linares R, Galej WP
Mol Cell (2024) 84 pp. 2542- [ Pubmed: 38823386 DOI: doi:10.1016/j.molcel.2024.05.009 ]
- Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
- Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
- Integrator ints5/8/15 subcomplex (Complex from Homo sapiens)
- Integrator complex subunit 15 (50 kDa, Protein from Homo sapiens)
Structure of the Integrator arm module containing subunits INTS10/13/14/15 (state 1)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 9fa4
Q-score: 0.262
Razew M, Fraudeau A, Pfleiderer MM, Linares R, Galej WP
Mol Cell (2024) 84 pp. 2542- [ Pubmed: 38823386 DOI: doi:10.1016/j.molcel.2024.05.009 ]
- Integrator complex subunit 14 (57 kDa, Protein from Homo sapiens)
- Integrator complex subunit 13 (80 kDa, Protein from Homo sapiens)
- Integrator complex subunit 10 (82 kDa, Protein from Homo sapiens)
- Structure of the integrator arm module containing subunits ints10/13/14/15 (state 1) (270 kDa, Complex from Homo sapiens)
- Integrator complex subunit 15 (50 kDa, Protein from Homo sapiens)
Structure of the Integrator arm module containing subunits INTS10/13/14/15 (state 3)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 9fa7
Q-score: 0.292
Razew M, Fraudeau A, Pfleiderer MM, Linares R, Galej WP
Mol Cell (2024) 84 pp. 2542- [ Pubmed: 38823386 DOI: doi:10.1016/j.molcel.2024.05.009 ]
- Integrator complex subunit 14 (57 kDa, Protein from Homo sapiens)
- Integrator complex subunit 13 (80 kDa, Protein from Homo sapiens)
- Integrator complex subunit 10 (82 kDa, Protein from Homo sapiens)
- Structure of the integrator arm module containing subunits ints10/13/14/15 (state 3) (270 kDa, Complex from Homo sapiens)
- Integrator complex subunit 15 (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of human U2 snRNP after ATP-dependent remodeling
Human 17S U2 snRNP 5' domain core
Resolution: 2.21 Å
EM Method: Single-particle
Fitted PDBs: 7q3l
Q-score: 0.479
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ Pubmed: 34822310 DOI: doi:10.1126/science.abm4245 ]
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Hiv tat-specific factor 1 (90 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Probable atp-dependent rna helicase ddx46 (117 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- 17s u2 snrnp (300 kDa, Complex)
- 17s u2 snrnp (Complex from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Hiv tat-specific factor 1 (Complex from Homo sapiens)
Substrate-bound A-like U2 snRNP
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 7q4o
Q-score: 0.464
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ Pubmed: 34822310 DOI: doi:10.1126/science.abm4245 ]
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Bps oligo (5 kDa, RNA from synthetic construct)
- Water (18 Da, Ligand)
- A-like u2 snrnp (1 MDa, Complex)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Bps oligo (Complex from synthetic construct)
- A-like u2 snrnp (Complex from Homo sapiens)
U2 snRNP after ATP-dependent remodelling
Resolution: 2.15 Å
EM Method: Single-particle
Fitted PDBs: 7q4p
Q-score: 0.629
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ Pubmed: 34822310 DOI: doi:10.1126/science.abm4245 ]
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Remodelled u2 snrnp (1 MDa, Complex from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)