Cryo-EM structure of human U2 snRNP after ATP-dependent remodeling
Human 17S U2 snRNP 5' domain core
Resolution: 2.21 Å
EM Method: Single-particle
Fitted PDBs: 7q3l
Q-score: 0.479
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ DOI: doi:10.1126/science.abm4245 Pubmed: 34822310 ]
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Water (18 Da, Ligand)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Hiv tat-specific factor 1 (Complex from Homo sapiens)
- Hiv tat-specific factor 1 (90 kDa, Protein from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Probable atp-dependent rna helicase ddx46 (117 kDa, Protein from Homo sapiens)
- 17s u2 snrnp (Complex from Homo sapiens)
- 17s u2 snrnp (300 kDa, Complex)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
Substrate-bound A-like U2 snRNP
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 7q4o
Q-score: 0.464
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ DOI: doi:10.1126/science.abm4245 Pubmed: 34822310 ]
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Water (18 Da, Ligand)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- A-like u2 snrnp (Complex from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- A-like u2 snrnp (1 MDa, Complex)
- Bps oligo (5 kDa, RNA from synthetic construct)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- Bps oligo (Complex from synthetic construct)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
U2 snRNP after ATP-dependent remodelling
Resolution: 2.15 Å
EM Method: Single-particle
Fitted PDBs: 7q4p
Q-score: 0.629
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ DOI: doi:10.1126/science.abm4245 Pubmed: 34822310 ]
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Water (18 Da, Ligand)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Remodelled u2 snrnp (1 MDa, Complex from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
A-like U2 snRNP medium-resolution map
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ DOI: doi:10.1126/science.abm4245 Pubmed: 34822310 ]
- A-like u2 snrnp (Complex from Homo sapiens)
- Bps oligo (Complex from synthetic construct)
- A-like u2 snrnp (300 kDa, Complex)
AMP-PCP-treated A-like U2 snRNP
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ DOI: doi:10.1126/science.abm4245 Pubmed: 34822310 ]
- A-like u2 snrnp (Complex from Homo sapiens)
- Bps oligo (Complex from synthetic construct)
- Amp-pcp-treated a-like u2 snrnp (300 kDa, Complex)
Human 17S U2 snRNP HEAT repeats
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ DOI: doi:10.1126/science.abm4245 Pubmed: 34822310 ]
- 17s u2 snrnp (1 MDa, Complex from Homo sapiens)
U2 snRNP 5' domain high resolution map
Tholen J, Razew M, Weis F, Galej WP
Science (2022) 375 pp. 50-57 [ DOI: doi:10.1126/science.abm4245 Pubmed: 34822310 ]
- U2 snrnp 3' domain (Complex from Homo sapiens)
- U2 snrnp 5' domain (Complex from Homo sapiens)
- U2 snrnp (300 kDa, Complex)