Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 1)
Resolution: 2.39 Å
EM Method: Helical reconstruction
Fitted PDBs: 8cg3
Q-score: 0.698
Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
Nature (2023) 620 pp. 898-903 [ Pubmed: 37532939 DOI: doi:10.1038/s41586-023-06405-w ]
Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 2)
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8cgg
Q-score: 0.67
Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
Nature (2023) 620 pp. 898-903 [ Pubmed: 37532939 DOI: doi:10.1038/s41586-023-06405-w ]
Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 3)
Resolution: 2.68 Å
EM Method: Helical reconstruction
Fitted PDBs: 8cgh
Q-score: 0.668
Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
Nature (2023) 620 pp. 898-903 [ Pubmed: 37532939 DOI: doi:10.1038/s41586-023-06405-w ]
Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ore
Q-score: 0.593
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ DOI: doi:10.1002/2211-5463.13657 Pubmed: 37337995 ]
- Tau amyloid filaments (Cell from Homo sapiens)
- Microtubule-associated protein tau (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8orf
Q-score: 0.601
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ DOI: doi:10.1002/2211-5463.13657 Pubmed: 37337995 ]
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
- Tau amyloid filaments (Cell from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II)
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8org
Q-score: 0.606
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ DOI: doi:10.1002/2211-5463.13657 Pubmed: 37337995 ]
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
- Tau amyloid filaments (Cell from Homo sapiens)
Progressive supranuclear palsy tau filament
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 7p65
Q-score: 0.608
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DMA, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
Nature (2021) 598 pp. 359-363 [ DOI: doi:10.1038/s41586-021-03911-7 Pubmed: 34588692 ]
Globular glial tauopathy type 1 tau filament
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 7p66
Q-score: 0.546
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DMA, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
Nature (2021) 598 pp. 359-363 [ DOI: doi:10.1038/s41586-021-03911-7 Pubmed: 34588692 ]
Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament
Resolution: 1.9 Å
EM Method: Helical reconstruction
Fitted PDBs: 7p6a
Q-score: 0.724
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DMA, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
Nature (2021) 598 pp. 359-363 [ DOI: doi:10.1038/s41586-021-03911-7 Pubmed: 34588692 ]
Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament
Resolution: 2.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 7p6b
Q-score: 0.694
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DMA, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
Nature (2021) 598 pp. 359-363 [ DOI: doi:10.1038/s41586-021-03911-7 Pubmed: 34588692 ]