Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 1)
Resolution: 2.39 Å
EM Method: Helical reconstruction
Fitted PDBs: 8cg3
Q-score: 0.698
Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
Nature (2023) 620 pp. 898-903 [ DOI: doi:10.1038/s41586-023-06405-w Pubmed: 37532939 ]
Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 2)
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8cgg
Q-score: 0.67
Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
Nature (2023) 620 pp. 898-903 [ DOI: doi:10.1038/s41586-023-06405-w Pubmed: 37532939 ]
Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 3)
Resolution: 2.68 Å
EM Method: Helical reconstruction
Fitted PDBs: 8cgh
Q-score: 0.668
Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
Nature (2023) 620 pp. 898-903 [ DOI: doi:10.1038/s41586-023-06405-w Pubmed: 37532939 ]
Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ore
Q-score: 0.593
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ Pubmed: 37337995 DOI: doi:10.1002/2211-5463.13657 ]
- Tau amyloid filaments (Cell from Homo sapiens)
- Microtubule-associated protein tau (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8orf
Q-score: 0.601
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ Pubmed: 37337995 DOI: doi:10.1002/2211-5463.13657 ]
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
- Tau amyloid filaments (Cell from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II)
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8org
Q-score: 0.606
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ Pubmed: 37337995 DOI: doi:10.1002/2211-5463.13657 ]
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
- Tau amyloid filaments (Cell from Homo sapiens)
Progressive supranuclear palsy tau filament
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 7p65
Q-score: 0.608
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DMA, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
Nature (2021) 598 pp. 359-363 [ DOI: doi:10.1038/s41586-021-03911-7 Pubmed: 34588692 ]
Globular glial tauopathy type 1 tau filament
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 7p66
Q-score: 0.546
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DMA, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
Nature (2021) 598 pp. 359-363 [ DOI: doi:10.1038/s41586-021-03911-7 Pubmed: 34588692 ]
Globular glial tauopathy type 2 tau filament
Resolution: 3.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 7p67
Q-score: 0.566
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DMA, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
Nature (2021) 598 pp. 359-363 [ DOI: doi:10.1038/s41586-021-03911-7 Pubmed: 34588692 ]
Globular glial tauopathy type 3 tau filament
Resolution: 2.9 Å
EM Method: Helical reconstruction
Fitted PDBs: 7p68
Q-score: 0.547
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DMA, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
Nature (2021) 598 pp. 359-363 [ DOI: doi:10.1038/s41586-021-03911-7 Pubmed: 34588692 ]