Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7uot
Q-score: 0.559
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ DOI: doi:10.1126/scitranslmed.abq0991 Pubmed: 36288283 ]
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- Native lassa glycoprotein in complex with 8.9f-scfv and 37.2d-scfv (Complex)
- 8.9f heavy chain (variable domain) (15 kDa, Protein from Homo sapiens)
- 8.9f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7uov
Q-score: 0.541
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ DOI: doi:10.1126/scitranslmed.abq0991 Pubmed: 36288283 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Native lassa glycoprotein in complex with 12.1f-scfv and 37.2d-scfv (Complex)
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- 12.1f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 12.1f heavy chain (variable domain) (12 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
Structure of lineage I (Pinneo) Lassa virus glycoprotein bound to Fab 25.10C
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uds
Q-score: 0.403
Buck TK, Enriquez AS, Schendel SL, Zandonatti MA, Harkins SS, Li H, Moon-Walker A, Robinson JE, Branco LM, Garry RF, Saphire EO, Hastie KM
Mbio (2022) 13 pp. e0127822-e0127822 [ Pubmed: 35730904 DOI: doi:10.1128/mbio.01278-22 ]
- 25.10c fab heavy chain (24 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (23 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein g1 (28 kDa, Protein from Lassa mammarenavirus)
- Lineage i lassa virus glycoprotein bound to fab 25.10c (350 kDa, Complex)
- 25.10c fab light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Lineage I (Pinneo) Lassa virus glycoprotein bound to 18.5C-M30 Fab
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7ul7
Q-score: 0.336
Buck TK, Enriquez AS, Schendel SL, Zandonatti MA, Harkins SS, Li H, Moon-Walker A, Robinson JE, Branco LM, Garry RF, Saphire EO, Hastie KM
Mbio (2022) 13 pp. e0127822-e0127822 [ DOI: doi:10.1128/mbio.01278-22 Pubmed: 35730904 ]
- Glycoprotein g1 (28 kDa, Protein from Lassa mammarenavirus)
- 18.5c-m30 fab heavy chain (26 kDa, Protein from Homo sapiens)
- Lineage i (pinneo) lassa virus glycoprotein bound to 18.5c-m30 fab (350 kDa, Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein g2 (23 kDa, Protein from Lassa mammarenavirus)
- 18.5c-m30 fab light chain (25 kDa, Protein from Homo sapiens)
Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7tyv
Q-score: 0.447
Enriquez AS, Buck TK, Li H, Norris MJ, Moon-Walker A, Zandonatti MA, Harkins SS, Robinson JE, Branco LM, Garry RF, Saphire EO, Hastie KM
Cell Rep (2022) 39 pp. 110841-110841 [ Pubmed: 35613585 DOI: doi:10.1016/j.celrep.2022.110841 ]
- 25.10c fab heavy chain (24 kDa, Protein from Homo sapiens)
- Lassa virus josiah gp complexed with anti-lassa virus antibody fab fragment 25.10c (350 kDa, Complex)
- Glycoprotein g2 (19 kDa, Protein from Lassa virus)
- 25.10c fab light chain (25 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
- Lassa virus glycoprotein josiah (Complex from Lassa virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 25.10c fab fragment (Complex from Homo sapiens)