Human proton sensing receptor GPR65 in complex with miniGs - focused map of 7TM
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbolle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
Cell (2024) [ DOI: doi:10.1016/j.cell.2024.11.036 Pubmed: 39753132 ]
- Gpr65 receptor in complex with minigs (Complex)
- Minigs (alpha and beta subunits) (Complex from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Gpr65 receptor (Complex from Homo sapiens)
Human proton sensing receptor GPR65 in complex with miniGs
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9bhl
Q-score: 0.375
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbolle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
Cell (2024) [ DOI: doi:10.1016/j.cell.2024.11.036 Pubmed: 39753132 ]
- Psychosine receptor (40 kDa, Protein from Homo sapiens)
- Complex of gpr65 bound to gs heterotrimer (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Human proton sensing receptor GPR68 in complex with miniGs
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bhm
Q-score: 0.456
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbolle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
Cell (2024) [ DOI: doi:10.1016/j.cell.2024.11.036 Pubmed: 39753132 ]
- Ovarian cancer g-protein coupled receptor 1 (42 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Complex of gpr68 bound to gs heterotrimer (Complex)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Human proton sensing receptor GPR68 in complex with miniGsq
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bi6
Q-score: 0.567
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbolle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
Cell (2024) [ DOI: doi:10.1016/j.cell.2024.11.036 Pubmed: 39753132 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Complex of gpr68 bound to gq heterotrimer (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Minigsq (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Ovarian cancer g-protein coupled receptor 1 (42 kDa, Protein from Homo sapiens)
Human proton sensing receptor GPR68 in complex with miniGsq - focused map of 7TM
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbolle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
Cell (2024) [ DOI: doi:10.1016/j.cell.2024.11.036 Pubmed: 39753132 ]
Human proton sensing receptor GPR4 in complex with miniGs - focused map of 7TM
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbolle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
Cell (2024) [ DOI: doi:10.1016/j.cell.2024.11.036 Pubmed: 39753132 ]
Human proton sensing receptor GPR4 in complex with miniGs
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9bip
Q-score: 0.567
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbolle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
Cell (2024) [ DOI: doi:10.1016/j.cell.2024.11.036 Pubmed: 39753132 ]
- G-protein coupled receptor 4 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Complex of gpr4 bound to gs heterotrimer (Complex from Homo sapiens)
- Minigs (30 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)