Photorhabdus luminescens TcdA1 prepore-to-pore intermediate, K1179W mutant
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8cpz
Q-score: 0.526
Ng'ang'a PN, Folz J, Kucher S, Roderer D, Xu Y, Sitsel O, Belyy A, Prumbaum D, Kuhnemuth R, Assafa TE, Dong M, Seidel CAM, Bordignon E, Raunser S
Sci Adv (2025) 11 pp. eadr2019-eadr2019 [ Pubmed: 39752508 DOI: doi:10.1126/sciadv.adr2019 ]
- Tcda1 (1 MDa, Complex from Photorhabdus luminescens)
- Tcda1 (285 kDa, Protein from Photorhabdus luminescens)
Photorhabdus luminescens TcdA1 prepore-to-pore intermediate, K567W K2008W mutant
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8cq0
Q-score: 0.466
Ng'ang'a PN, Folz J, Kucher S, Roderer D, Xu Y, Sitsel O, Belyy A, Prumbaum D, Kuhnemuth R, Assafa TE, Dong M, Seidel CAM, Bordignon E, Raunser S
Sci Adv (2025) 11 pp. eadr2019-eadr2019 [ Pubmed: 39752508 DOI: doi:10.1126/sciadv.adr2019 ]
- Tcda1 (1 MDa, Complex from Photorhabdus luminescens)
- Tcda1 (285 kDa, Protein from Photorhabdus luminescens)
Photorhabdus luminescens TcdA1 prepore-to-pore intermediate, C16S, C20S, C870S, T1279C mutant
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8cq2
Q-score: 0.448
Ng'ang'a PN, Folz J, Kucher S, Roderer D, Xu Y, Sitsel O, Belyy A, Prumbaum D, Kuhnemuth R, Assafa TE, Dong M, Seidel CAM, Bordignon E, Raunser S
Sci Adv (2025) 11 pp. eadr2019-eadr2019 [ Pubmed: 39752508 DOI: doi:10.1126/sciadv.adr2019 ]
- Tcda1 (1 MDa, Complex from Photorhabdus luminescens)
- Tcda1 (285 kDa, Protein from Photorhabdus luminescens)
Structure of P. luminescens TccC3-F-actin complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7z7h
Q-score: 0.366
Belyy A, Lindemann F, Roderer D, Funk J, Bardiaux B, Protze J, Bieling P, Oschkinat H, Raunser S
Nat Commun (2022) 13 pp. 4202-4202 [ Pubmed: 35858890 DOI: doi:10.1038/s41467-022-31836-w ]
- Magnesium ion (24 Da, Ligand)
- Maltose/maltodextrin-binding periplasmic protein,tccc3 (63 kDa, Protein from Photorhabdus luminescens)
- Nicotinamide (122 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Structure of p. luminescence tccc3-f-actin complex (Complex from Photorhabdus luminescens)
- Actin, alpha skeletal muscle (42 kDa, Protein from rabbit)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
Photorhabdus luminescens TcdA1 in complex with BSA-Lewis X
Roderer D, Brocker F, Sitsel O, Kaplonek P, Leidreiter F, Seeberger PH, Raunser S
Nat Commun (2020) 11 pp. 2694-2694 [ Pubmed: 32483155 DOI: doi:10.1038/s41467-020-16536-7 ]
- Photorhabdus luminescens tcda1 pentamer with one bsa-lewis x, crosslinked with glutaraldehyde (1 MDa, Complex)
- Photorhabdus luminescens toxin complex subunit tcda1, homopentamer (Protein from Photorhabdus luminescens)
- Bsa with lewis x glycans crosslinked to surface lysines (Protein from Bos taurus)
- Bsa with lewis x glycans crosslinked to surface lysines (Complex from Bos taurus)
- Photorhabdus luminescens toxin complex subunit tcda1, homopentamer (Complex from Photorhabdus luminescens)
Tc holotoxin prepore TcdA1-TcdB2-TccC3-Cdc42
Roderer D, Schubert E, Sitsel O, Raunser S
Nat Commun (2019) 10 pp. 5263-5263 [ DOI: doi:10.1038/s41467-019-13253-8 Pubmed: 31748551 ]
Structure of Photorhabdus luminescens Tc holotoxin pore, Mutation TccC3-D651A
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6sue
Q-score: 0.385
Roderer D, Hofnagel O, Benz R, Raunser S
PNAS (2019) 116 pp. 23083-23090 [ Pubmed: 31666324 DOI: doi:10.1073/pnas.1909821116 ]
- Tcda1 (283 kDa, Protein from Photorhabdus luminescens)
- Tcdb2,tccc3 (274 kDa, Protein from Photorhabdus luminescens)
- Tc holotoxin composed of the tcda1 pentamer and tcdb2-tccc3 (1 MDa, Complex from Photorhabdus luminescens)
Structure of Photorhabdus luminescens Tc holotoxin pore
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6suf
Q-score: 0.396
Roderer D, Hofnagel O, Benz R, Raunser S
PNAS (2019) 116 pp. 23083-23090 [ Pubmed: 31666324 DOI: doi:10.1073/pnas.1909821116 ]
- Tcda1 (283 kDa, Protein from Photorhabdus luminescens)
- Tc holotoxin complex in the pore form, formed by the tcda1 pentamer and tcdb2-tccc3 (1 MDa, Complex from Photorhabdus luminescens)
- Tcdb2,tccc3 (274 kDa, Protein from Photorhabdus luminescens)
Cryo-EM structure of Photorhabdus luminescens TcdA1
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 6rw6
Q-score: 0.585
Leidreiter F, Roderer D, Meusch D, Gatsogiannis C, Benz R, Raunser S
Sci Adv (2019) 5 pp. eaax6497-eaax6497 [ DOI: doi:10.1126/sciadv.aax6497 Pubmed: 31663026 ]
- Tcda1 (283 kDa, Protein from Photorhabdus luminescens)
- Tcda1 pentamer (1 MDa, Complex from Photorhabdus luminescens)
Cryo-EM structure of Photorhabdus luminescens TcdA4
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6rwa
Q-score: 0.352
Leidreiter F, Roderer D, Meusch D, Gatsogiannis C, Benz R, Raunser S
Sci Adv (2019) 5 pp. eaax6497-eaax6497 [ DOI: doi:10.1126/sciadv.aax6497 Pubmed: 31663026 ]
- P. luminescens tcda4 pentamer (1 MDa, Complex from Photorhabdus luminescens)
- Tcda4 (270 kDa, Protein from Photorhabdus luminescens)