Structure of the IL-5 Signaling Complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tld
Q-score: 0.409
Caveney NA, Rodriguez GE, Pollmann C, Meyer T, Borowska MT, Wilson SC, Wang N, Xiang X, Householder KD, Tao P, Su LL, Saxton RA, Piehler J, Garcia KC
Mol Cell (2024) 84 pp. 1995-2005.e7 [ DOI: doi:10.1016/j.molcel.2024.03.023 Pubmed: 38614096 ]
- Il-5 receptor complex (Complex from Homo sapiens)
- Cytokine receptor common subunit beta (81 kDa, Protein from Homo sapiens)
- Interleukin-5 receptor subunit alpha (44 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-5 (16 kDa, Protein from Homo sapiens)
Caveney NA, Rodriguez GE, Pollmann C, Meyer T, Borowska MT, Wilson SC, Wang N, Xiang X, Householder KD, Tao P, Su LL, Saxton RA, Piehler J, Garcia KC
Mol Cell (2024) 84 pp. 1995-2005.e7 [ DOI: doi:10.1016/j.molcel.2024.03.023 Pubmed: 38614096 ]
- Cytokine receptor common subunit beta (Protein from Homo sapiens)
- Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (Protein from Homo sapiens)
- Gm-csf receptor complex (Complex from Homo sapiens)
- Granulocyte-macrophage colony-stimulating factor (Protein from Homo sapiens)
Caveney NA, Rodriguez GE, Pollmann C, Meyer T, Borowska MT, Wilson SC, Wang N, Xiang X, Householder KD, Tao P, Su LL, Saxton RA, Piehler J, Garcia KC
Mol Cell (2024) 84 pp. 1995-2005.e7 [ DOI: doi:10.1016/j.molcel.2024.03.023 Pubmed: 38614096 ]
- Common beta receptor (Protein)
- Il-3 receptor complex (Complex from Homo sapiens)
- Il-3 (Protein)
- Il-3 receptor alpha (Protein)
CryoEM micrographs of the leptin–leptin receptor complex
Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC
Nat Commun (2023) 14 [ Pubmed: 37002197 DOI: 10.1038/s41467-023-37169-6 ]
Image sets:
Leptin-bound leptin receptor complex-full ECD
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 8dh8
Q-score: 0.118
Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC
Nat Commun (2023) 14 pp. 1797-1797 [ Pubmed: 37002197 DOI: doi:10.1038/s41467-023-37169-6 ]
- Leptin receptor (97 kDa, Protein from Mus musculus)
- Leptin (15 kDa, Protein from Mus musculus)
- Leptin receptor complex (Complex from Mus musculus)
Leptin-bound leptin receptor complex-D3-D7
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8dh9
Q-score: 0.065
Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC
Nat Commun (2023) 14 pp. 1797-1797 [ Pubmed: 37002197 DOI: doi:10.1038/s41467-023-37169-6 ]
- Leptin receptor (63 kDa, Protein from Mus musculus)
- Leptin receptor complex (Complex from Mus musculus)
- Leptin (18 kDa, Protein from Mus musculus)
Leptin-bound leptin receptor complex- focused interaction
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8dha
Q-score: 0.422
Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC
Nat Commun (2023) 14 pp. 1797-1797 [ Pubmed: 37002197 DOI: doi:10.1038/s41467-023-37169-6 ]
- Leptin receptor complex (Complex from Mus musculus)
- Leptin receptor (63 kDa, Protein from Mus musculus)
- Leptin (16 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)