Structure of alpha1B and betaI/IVb microtubule bound to GDP
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8v2j
Q-score: 0.52
To Be Published
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Dynamic alpha1b and betai/ivb microtubule (400 kDa, Complex from Homo sapiens)
Cryo electron micrographs of CCP5 decorated microtubules
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024) 631 pp. 905-912 [ Pubmed: 39020174 DOI: 10.1038/s41586-024-07699-0 ]
Image sets:
Microtubule protofilament reconstruction in CCP5:microtubule class#1 complex
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024) 631 pp. 905-912 [ DOI: doi:10.1038/s41586-024-07699-0 Pubmed: 39020174 ]
Microtubule protofilament reconstruction in CCP5:microtubule class#2 complex
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024) 631 pp. 905-912 [ DOI: doi:10.1038/s41586-024-07699-0 Pubmed: 39020174 ]
Microtubule Protofilament reconstruction in CCP5:microtubule class#3 complex
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024) 631 pp. 905-912 [ DOI: doi:10.1038/s41586-024-07699-0 Pubmed: 39020174 ]
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8v3q
Q-score: 0.542
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024) 631 pp. 905-912 [ DOI: doi:10.1038/s41586-024-07699-0 Pubmed: 39020174 ]
- Ccp5 in complex with beta tubulin tail (Complex)
- Beta tubulin tail (827 Da, Protein from Sus scrofa)
- Glutamic acid (147 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cytosolic carboxypeptidase-like protein 5 (68 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8v3r
Q-score: 0.49
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024) 631 pp. 905-912 [ DOI: doi:10.1038/s41586-024-07699-0 Pubmed: 39020174 ]
- Beta tubulin tail (487 Da, Protein from Sus scrofa)
- Ccp5 in complex with beta tubulin tail (Complex)
- Glutamic acid (147 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cytosolic carboxypeptidase-like protein 5 (68 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8v3s
Q-score: 0.456
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024) 631 pp. 905-912 [ DOI: doi:10.1038/s41586-024-07699-0 Pubmed: 39020174 ]
- Beta tubulin tail (487 Da, Protein from Sus scrofa)
- Ccp5 in complex with beta tubulin tail (Complex)
- Glutamic acid (147 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cytosolic carboxypeptidase-like protein 5 (68 kDa, Protein from Homo sapiens)
CCP5 in complex with microtubules class1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8v4k
Q-score: 0.501
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024) 631 pp. 905-912 [ DOI: doi:10.1038/s41586-024-07699-0 Pubmed: 39020174 ]
- Ccp5 in complex with microtubules (Complex)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin alpha-1b chain (50 kDa, Protein from Sus scrofa)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cytosolic carboxypeptidase-like protein 5 (68 kDa, Protein from Homo sapiens)
CCP5 in complex with microtubules class2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8v4l
Q-score: 0.499
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024) 631 pp. 905-912 [ DOI: doi:10.1038/s41586-024-07699-0 Pubmed: 39020174 ]
- Ccp5 in complex with microtubules (Complex)
- Tubulin beta chain (50 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin alpha-1b chain (50 kDa, Protein from Sus scrofa)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cytosolic carboxypeptidase-like protein 5 (68 kDa, Protein from Homo sapiens)