Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7txt
Q-score: 0.549
Singh I, Seth A, Billesbolle CB, Braz J, Rodriguiz RM, Roy K, Bekele B, Craik V, Huang XP, Boytsov D, Pogorelov VM, Lak P, O'Donnell H, Sandtner W, Irwin JJ, Roth BL, Basbaum AI, Wetsel WC, Manglik A, Shoichet BK, Rudnick G
Cell (2023) 186 pp. 2160-2175.e17 [ Pubmed: 37137306 DOI: doi:10.1016/j.cell.2023.04.010 ]
- Fab15b8 heavy chain (Complex from Mus musculus)
- Fab15b8 light chain (Complex from Mus musculus)
- Human serotonin transporter in complex with fab15b8 bound to '8090 in nacl (Complex)
- 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine (263 Da, Ligand)
- Sodium-dependent serotonin transporter (61 kDa, Protein from Homo sapiens)
- Sodium-dependent serotonin transporter (Complex from Homo sapiens)
- 15b8 fab light chain (11 kDa, Protein from Mus musculus)
- 15b8 fab heavy chain (13 kDa, Protein from Mus musculus)
Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide
Zhao Y, Roy K, Vidossich P, Cancedda L, De Vivo M, Forbush B, Cao E
Nat Commun (2022) 13 [ Pubmed: 35585053 DOI: 10.1038/s41467-022-30407-3 ]
Image sets:
Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide
Zhao Y, Roy K, Vidossich P, Cancedda L, De Vivo M, Forbush B, Cao E
Nat Commun (2022) 13 [ Pubmed: 35585053 DOI: 10.1038/s41467-022-30407-3 ]
Image sets:
Cryo-EM structure of human NKCC1 K289NA492E bound with Furosemide
Zhao Y, Roy K, Vidossich P, Cancedda L, De Vivo M, Forbush B, Cao E
Nat Commun (2022) 13 [ Pubmed: 35585053 DOI: 10.1038/s41467-022-30407-3 ]
Image sets:
Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7s1x
Q-score: 0.515
Zhao Y, Roy K, Vidossich P, Cancedda L, De Vivo M, Forbush B, Cao E
Nat Commun (2022) 13 pp. 2747- [ DOI: doi:10.1038/s41467-022-30407-3 ]
- Chloride ion (35 Da, Ligand)
- Human nkcc1 k289na492el671c bound with bumetanide (263 kDa, Complex from Homo sapiens)
- 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid (364 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Solute carrier family 12 member 2 (131 kDa, Protein from Homo sapiens)
Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7s1y
Q-score: 0.35
Zhao Y, Roy K, Vidossich P, Cancedda L, De Vivo M, Forbush B, Cao E
Nat Commun (2022) 13 pp. 2747- [ DOI: doi:10.1038/s41467-022-30407-3 ]
- Chloride ion (35 Da, Ligand)
- 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid (364 Da, Ligand)
- Solute carrier family 12 member 2 (131 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Hnkcc1 k289na492e bound with bumetanide (Complex from Homo sapiens)
Cryo-EM structure of Human NKCC1 K289NA492EL671C
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7s1z
Q-score: 0.404
Zhao Y, Roy K, Vidossich P, Cancedda L, De Vivo M, Forbush B, Cao E
Nat Commun (2022) 13 pp. 2747- [ DOI: doi:10.1038/s41467-022-30407-3 ]
- Human nkcc1 k289na492el671c (Complex from Homo sapiens)
- Solute carrier family 12 member 2 (131 kDa, Protein from Homo sapiens)
Human NKCC1 K289NA492E Bound with Furosemide
Zhao Y, Roy K, Vidossich P, Cancedda L, De Vivo M, Forbush B, Cao E
Nat Commun (2022) 13 pp. 2747- [ DOI: doi:10.1038/s41467-022-30407-3 ]
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 7d10
Q-score: 0.501
Zhang S, Zhou J, Zhang Y, Liu T, Friedel P, Zhuo W, Somasekharan S, Roy K, Zhang L, Liu Y, Meng X, Deng H, Zeng W, Li G, Forbush B, Yang M
Commun Biol (2021) 4 pp. 226-226 [ Pubmed: 33597714 DOI: doi:10.1038/s42003-021-01750-w ]
- Palmitic acid (256 Da, Ligand)
- Solute carrier family 12 member 2 (131 kDa, Protein from Homo sapiens)
- Human nkcc1 (Complex from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7d14
Q-score: 0.472
Zhang S, Zhou J, Zhang Y, Liu T, Friedel P, Zhuo W, Somasekharan S, Roy K, Zhang L, Liu Y, Meng X, Deng H, Zeng W, Li G, Forbush B, Yang M
Commun Biol (2021) 4 pp. 226-226 [ Pubmed: 33597714 DOI: doi:10.1038/s42003-021-01750-w ]
- Mouse kcc2 (Cellular component from Mus musculus)
- Solute carrier family 12 member 5 (126 kDa, Protein from Mus musculus)