cryo-EM structure of human proton-activated chloride channel PAC at pH 8
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7jna
Q-score: 0.398
Ruan Z, Osei-Owusu J, Du J, Qiu Z, Lu W
Nature (2020) 588 pp. 350-354 [ DOI: doi:10.1038/s41586-020-2875-7 Pubmed: 33149300 ]
cryo-EM structure of human proton-activated chloride channel PAC at pH 4
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7jnc
Q-score: 0.386
Ruan Z, Osei-Owusu J, Du J, Qiu Z, Lu W
Nature (2020) 588 pp. 350-354 [ DOI: doi:10.1038/s41586-020-2875-7 Pubmed: 33149300 ]
Cryo-EM structure of wild type human Pannexin 1 channel
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 6wbf
Q-score: 0.492
Nature (2020) 584 pp. 646-651 [ Pubmed: 32494015 DOI: doi:10.1038/s41586-020-2357-y ]
- Wild type human pannexin 1 channel (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Pannexin-1 (42 kDa, Protein from Homo sapiens)
- Diacyl glycerol (625 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 6wbg
Q-score: 0.514
Nature (2020) 584 pp. 646-651 [ Pubmed: 32494015 DOI: doi:10.1038/s41586-020-2357-y ]
- Wild type human pannexin 1 channel (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Pannexin-1 (42 kDa, Protein from Homo sapiens)
- Diacyl glycerol (625 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Resolution: 4.39 Å
EM Method: Single-particle
Fitted PDBs: 6wbi
Q-score: 0.334
Nature (2020) 584 pp. 646-651 [ Pubmed: 32494015 DOI: doi:10.1038/s41586-020-2357-y ]
- Wild type human pannexin 1 channel (Complex from Homo sapiens)
- Carbenoxolone (570 Da, Ligand)
- Pannexin-1 (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of human Pannexin 1 channel with deletion of N-terminal helix and C-terminal tail
Resolution: 6.01 Å
EM Method: Single-particle
Fitted PDBs: 6wbk
Q-score: 0.268
Nature (2020) 584 pp. 646-651 [ Pubmed: 32494015 DOI: doi:10.1038/s41586-020-2357-y ]
- Pannexin-1 (41 kDa, Protein from Homo sapiens)
- Wild type human pannexin 1 channel (Complex from Homo sapiens)
Resolution: 5.13 Å
EM Method: Single-particle
Fitted PDBs: 6wbl
Q-score: 0.266
Nature (2020) 584 pp. 646-651 [ Pubmed: 32494015 DOI: doi:10.1038/s41586-020-2357-y ]
- Pannexin-1 (41 kDa, Protein from Homo sapiens)
- Wild type human pannexin 1 channel (Complex from Homo sapiens)
- Carbenoxolone (570 Da, Ligand)
Cryo-EM structure of human Pannexin 1 channel N255A mutant
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 6wbm
Q-score: 0.47
Nature (2020) 584 pp. 646-651 [ Pubmed: 32494015 DOI: doi:10.1038/s41586-020-2357-y ]
- Wild type human pannexin 1 channel (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Pannexin-1 (42 kDa, Protein from Homo sapiens)
- Diacyl glycerol (625 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of human Pannexin 1 channel N255A mutant, gap junction
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 6wbn
Q-score: 0.48
Nature (2020) 584 pp. 646-651 [ Pubmed: 32494015 DOI: doi:10.1038/s41586-020-2357-y ]
- Wild type human pannexin 1 channel (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Pannexin-1 (42 kDa, Protein from Homo sapiens)
- Diacyl glycerol (625 Da, Ligand)
- Cholesterol (386 Da, Ligand)