SAN27-14 bound to a antigenic site V on prefusion-stabilized hMPV F
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7tjq
Q-score: 0.511
Rush SA, Brar G, Hsieh CL, Chautard E, Rainho-Tomko JN, Slade CD, Bricault CA, Kume A, Kearns J, Groppo R, Mundle ST, Zhang L, Casimiro D, Fu TM, DiNapoli JM, McLellan JS
Cell Rep (2022) 40 pp. 111399-111399 [ DOI: doi:10.1016/j.celrep.2022.111399 Pubmed: 36130517 ]
- Fusion glycoprotein f0 (60 kDa, Protein from Human metapneumovirus)
- San27-14 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Mpe8 fab light chain (22 kDa, Protein from Homo sapiens)
- Mpe8 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Complex of hmpv f with mpe8 fab and san27-14 fab (Complex from Homo sapiens)
- San27-14 fab light chain (12 kDa, Protein from Homo sapiens)
Cryo-EM structure of hMPV preF bound by Fabs MPE8 and SAN32-2
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 7tl0
Q-score: 0.521
Rush SA, Brar G, Hsieh CL, Chautard E, Rainho-Tomko JN, Slade CD, Bricault CA, Kume A, Kearns J, Groppo R, Mundle ST, Zhang L, Casimiro D, Fu TM, DiNapoli JM, McLellan JS
Cell Rep (2022) 40 pp. 111399-111399 [ DOI: doi:10.1016/j.celrep.2022.111399 Pubmed: 36130517 ]
- Fusion glycoprotein f0 (60 kDa, Protein from Human metapneumovirus)
- San32-2 fab light chain (23 kDa, Protein from Homo sapiens)
- San32-2 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Mpe8 fab light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Trimeric prefusion hmpv f glycoprotein bound by three molecules of fabs san32-2 and mpe8 (457 MDa, Complex from Human metapneumovirus)
- Mpe8 fab heavy chain (23 kDa, Protein from Homo sapiens)
Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8cw9
Q-score: 0.419
Rappazzo CG, Hsieh CL, Rush SA, Esterman ES, Delgado T, Geoghegan JC, Wec AZ, Sakharkar M, Mas V, McLellan JS, Walker LM
Immunity (2022) 55 pp. 1710-1724.e8 [ Pubmed: 35944529 DOI: doi:10.1016/j.immuni.2022.07.003 ]
- Fusion glycoprotein f0 (60 kDa, Protein from Human metapneumovirus)
- Mpe8 light chain (22 kDa, Protein from Homo sapiens)
- Adi-61026 light (22 kDa, Protein from Homo sapiens)
- Hmpv fusion protein bound to adi-61026 and mpe8 fabs (Complex from Human metapneumovirus)
- Adi-61026 heavy (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mpe8 heavy chain (49 kDa, Protein from Homo sapiens)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7ur4
Q-score: 0.487
Banerjee A, Huang J, Rush SA, Murray J, Gingerich AD, Royer F, Hsieh CL, Tripp RA, McLellan JS, Mousa JJ
PNAS (2022) 119 pp. e2203326119-e2203326119 [ Pubmed: 35696580 DOI: doi:10.1073/pnas.2203326119 ]
- Mpv467 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Fusion glycoprotein f0 (60 kDa, Protein from Human metapneumovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Trimeric prefusion hmpv f glycoprotein bound by three molecules of mpv467 fab (Complex from Human metapneumovirus)
- Mpv467 fab light chain (22 kDa, Protein from Homo sapiens)
Prefusion RSV F glycoprotein bound by neutralizing site V-directed antibody ADI-14442
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7lue
Q-score: 0.572
Mukhamedova M, Wrapp D, Shen CH, Gilman MSA, Ruckwardt TJ, Schramm CA, Ault L, Chang L, Derrien-Colemyn A, Lucas SAM, Ransier A, Darko S, Phung E, Wang L, Zhang Y, Rush SA, Madan B, Stewart-Jones GBE, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Doria-Rose NA, Morabito KM, DeKosky BJ, Gaudinski MR, Chen GL, Crank MC, Misasi J, Sullivan NJ, Douek DC, Kwong PD, Graham BS, McLellan JS, Mascola JR
Immunity (2021) 54 pp. 769-780.e6 [ DOI: doi:10.1016/j.immuni.2021.03.004 Pubmed: 33823129 ]
- Trimeric prefusion rsv f glycoprotein (Complex from Respiratory syncytial virus A2)
- Light chain of human antibody fab adi-14442 (24 kDa, Protein from Homo sapiens)
- Fusion glycoprotein f0 (61 kDa, Protein from Respiratory syncytial virus A2)
- Fab adi-14442 (Complex from Homo sapiens)
- Heavy chain of human antibody fab adi-14442 (23 kDa, Protein from Homo sapiens)
- Trimeric prefusion rsv f glycoprotein bound by three molecules of fab adi-14442. (Complex from Respiratory syncytial virus A2)
Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 7luc
Q-score: 0.375
Mukhamedova M, Wrapp D, Shen CH, Gilman MSA, Ruckwardt TJ, Schramm CA, Ault L, Chang L, Derrien-Colemyn A, Lucas SAM, Ransier A, Darko S, Phung E, Wang L, Zhang Y, Rush SA, Madan B, Stewart-Jones GBE, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Doria-Rose NA, Morabito KM, DeKosky BJ, Gaudinski MR, Chen GL, Crank MC, Misasi J, Sullivan NJ, Douek DC, Kwong PD, Graham BS, McLellan JS, Mascola JR
Immunity (2021) 54 pp. 769-780.e6 [ DOI: doi:10.1016/j.immuni.2021.03.004 Pubmed: 33823129 ]
- Fusion glycoprotein f0 (58 kDa, Protein from Respiratory syncytial virus)
- 01.4b fab light chain (12 kDa, Protein from Homo sapiens)
- 32.4k fab heavy chain (14 kDa, Protein from Homo sapiens)
- Prefusion rsv f bound by fabs 01.4b and 32.4k (440 kDa, Complex from Respiratory syncytial virus)
- 32.4k fab light chain (11 kDa, Protein from Homo sapiens)
- 01.4b fab heavy chain (13 kDa, Protein from Homo sapiens)