GPR3 Orphan G-coupled Protein Receptor in complex with Dominant Negative Gs.
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8u8f
Q-score: 0.422
Russell IC, Zhang X, Bumbak F, McNeill SM, Josephs TM, Leeming MG, Christopoulos G, Venugopal H, Flocco MM, Sexton PM, Wootten D, Belousoff MJ
Biochemistry (2024) 63 pp. 625-631 [ DOI: doi:10.1021/acs.biochem.3c00647 Pubmed: 38376112 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Active state, gpr3 complex with dominant negative g-alphas. (Complex from Homo sapiens)
- G-protein coupled receptor 3 (41 kDa, Protein from Homo sapiens)
Human PTH1R in complex with PTH(1-34) and Gs
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8flq
Q-score: 0.538
Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM
Structure (2023) 31 pp. 668-676.e5 [ DOI: doi:10.1016/j.str.2023.04.002 Pubmed: 37148874 ]
- Nanobody35 (13 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (69 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Pth bound to the pth1r in complex with g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Human PTH1R in complex with PTHrP and Gs
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8flr
Q-score: 0.516
Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM
Structure (2023) 31 pp. 668-676.e5 [ DOI: doi:10.1016/j.str.2023.04.002 Pubmed: 37148874 ]
- Nanobody35 (13 kDa, Protein from Lama glama)
- Pthrp[1-36] (4 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (69 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Pthrp bound to the pth1r in complex with g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Human PTH1R in complex with Abaloparatide and Gs
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8fls
Q-score: 0.473
Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM
Structure (2023) 31 pp. 668-676.e5 [ DOI: doi:10.1016/j.str.2023.04.002 Pubmed: 37148874 ]
- Nanobody35 (13 kDa, Protein from Lama glama)
- Abaloparatide (3 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (69 kDa, Protein from Homo sapiens)
- Abaloparatide bound to the pth1r in complex with g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Human PTH1R in complex with M-PTH(1-14) and Gs
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8flt
Q-score: 0.528
Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM
Structure (2023) 31 pp. 668-676.e5 [ DOI: doi:10.1016/j.str.2023.04.002 Pubmed: 37148874 ]
- Nanobody35 (13 kDa, Protein from Lama glama)
- Human pth1r in complex with m-pth(1-14) and gs (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (69 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- M-pth(1-14) (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Human PTH1R in complex with LA-PTH and Gs
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8flu
Q-score: 0.463
Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM
Structure (2023) 31 pp. 668-676.e5 [ DOI: doi:10.1016/j.str.2023.04.002 Pubmed: 37148874 ]
- Long-acting pth (4 kDa, Protein from synthetic construct)
- Nanobody35 (13 kDa, Protein from Lama glama)
- Human pth1r in complex with la-pth and gs (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (69 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)