Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III (composite map)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7pt6
Q-score: 0.525
Saleh A, Noguchi Y, Aramayo R, Ivanova ME, Stevens KM, Montoya A, Sunidhi S, Carranza NL, Skwark MJ, Speck C
Nat Commun (2022) 13 pp. 2915-2915 [ Pubmed: 35614055 DOI: doi:10.1038/s41467-022-30576-1 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Mcm2-7 double hexamer bound to two copies of cdc7-dbf4 (1 MDa, Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ddk kinase regulatory subunit dbf4 (80 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
- Undefined mcm4 flexible n-terminal tail (358 Da, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Cell division control protein 7 (58 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ADP:BeF3, state I (composite map)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7pt7
Q-score: 0.445
Saleh A, Noguchi Y, Aramayo R, Ivanova ME, Stevens KM, Montoya A, Sunidhi S, Carranza NL, Skwark MJ, Speck C
Nat Commun (2022) 13 pp. 2915-2915 [ Pubmed: 35614055 DOI: doi:10.1038/s41467-022-30576-1 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mcm2-7 double hexamer bound to one copy of cdc7-dbf4 (1 MDa, Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ddk kinase regulatory subunit dbf4 (80 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
- Undefined mcm4 flexible n-terminal tail (358 Da, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Beryllium trifluoride ion (66 Da, Ligand)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Cell division control protein 7 (58 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
The structure of the dimeric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6z2j
Q-score: 0.314
Turnbull RE, Fairall L, Saleh A, Kelsall E, Morris KL, Ragan TJ, Savva CG, Chandru A, Millard CJ, Makarova OV, Smith CJ, Roseman AM, Fry AM, Cowley SM, Schwabe JWR
Nat Commun (2020) 11 pp. 3252-3252 [ Pubmed: 32591534 DOI: doi:10.1038/s41467-020-17078-8 ]
- Zinc ion (65 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Deoxynucleotidyltransferase terminal-interacting protein 1 (14 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Dimeric complex of the midac deacetylase complex containing hdac1, the elm2-sant domain of mideas and the dimerisation domain of dnttip1 (178 kDa, Complex from Homo sapiens)
- Histone deacetylase 1 (55 kDa, Protein from Homo sapiens)
- Mitotic deacetylase-associated sant domain protein (19 kDa, Protein from Homo sapiens)
The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6z2k
Q-score: 0.206
Turnbull RE, Fairall L, Saleh A, Kelsall E, Morris KL, Ragan TJ, Savva CG, Chandru A, Millard CJ, Makarova OV, Smith CJ, Roseman AM, Fry AM, Cowley SM, Schwabe JWR
Nat Commun (2020) 11 pp. 3252-3252 [ Pubmed: 32591534 DOI: doi:10.1038/s41467-020-17078-8 ]
- Zinc ion (65 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Tetrameric complex of the midac deacetylase complex containing hdac1, the elm2-sant domain of mideas and the dimerisation domain of dnttip1 (357 kDa, Complex from Homo sapiens)
- Deoxynucleotidyltransferase terminal-interacting protein 1 (14 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Histone deacetylase 1 (55 kDa, Protein from Homo sapiens)
- Mitotic deacetylase-associated sant domain protein (19 kDa, Protein from Homo sapiens)