KZ52 Fab fragment bound to Ebola GP, subtomogram average from a tight mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
KZ52 Fab fragment bound to Ebola GP, subtomogram average from a cylinder mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
3A6 Fab fragment bound to Ebola GP, subtomogram average from a cylinder mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
3A6 and KZ52 Fab fragments bound to Ebola GP, subtomogram average from a tight mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
3A6 and KZ52 Fab fragments bound to Ebola GP, subtomogram average from a cylinder mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8dpl
Q-score: 0.536
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2.1.1d5 light chain variable domain (11 kDa, Protein from Homo sapiens)
- 6d6 single-chain variable fragment (25 kDa, Protein from Mus musculus)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Structure of ebov gp in complex with 2.1.1d5 scfv and 6d6 scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2.1.1d5 heavy chain variable domain (13 kDa, Protein from Homo sapiens)
Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dpm
Q-score: 0.505
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- Antibody 9.20.1a2 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody 6d6 scfv (25 kDa, Protein from Mus musculus)
- Antibody 9.20.1a2 fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Complex of ebola virus glycoprotein trimer with 1a2 antibody fab and 6d6 antibody scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 9.20.1a2 fab heavy chain (13 kDa, Protein from Homo sapiens)
Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7swd
Q-score: 0.449
Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, Buck T, Heinrich ML, Branco LM, Crozier I, Holbrook MR, Kuhn JH, Kawaoka Y, Glass PJ, Bukreyev A, Geisbert TW, Worwa G, Ahmed R, Saphire EO
Cell (2022) 185 pp. 995-1007.e18 [ Pubmed: 35303429 DOI: doi:10.1016/j.cell.2022.02.023 ]
- Complex of ebov gp lacking the mucin-like-domain with 1c11 scfv and 1c3 fab (300 kDa, Complex from Homo sapiens)
- 1c3 light chain (12 kDa, Protein from Homo sapiens)
- 1c3 heavy chain (13 kDa, Protein from Homo sapiens)
- 1c11 scfv (26 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein gp2 (10 kDa, Protein from Zaire ebolavirus)
- Virion spike glycoprotein gp1 (31 kDa, Protein from Ebola virus - Gabon (1994-1997))
VIC170 Fab in complex with Ebola virus GP
Saphire EO, Schendel SL, Fusco ML, Gangavarapu K, Gunn BM, Wec AZ, Halfmann PJ, Brannan JM, Herbert AS, Qiu X, Wagh K, He S, Giorgi EE, Theiler J, Pommert KBJ, Krause TB, Turner HL, Murin CD, Pallesen J, Davidson E, Ahmed R, Aman MJ, Bukreyev A, Burton DR, Crowe Jr. JE, Davis CW, Georgiou G, Krammer F, Kyratsous CA, Lai JR, Nykiforuk C, Pauly MH, Rijal P, Takada A, Townsend AR, Volchkov V, Walker LM, Wang CI, Zeitlin L, Doranz BJ, Ward AB, Korber B, Kobinger GP, Andersen KG, Kawaoka Y, Alter G, Chandran K, Dye JM
Cell (2018) 174 pp. 938-952.e13 [ DOI: doi:10.1016/j.cell.2018.07.033 Pubmed: 30096313 ]
VIC169 Fab in complex with Ebola virus GP
Saphire EO, Schendel SL, Fusco ML, Gangavarapu K, Gunn BM, Wec AZ, Halfmann PJ, Brannan JM, Herbert AS, Qiu X, Wagh K, He S, Giorgi EE, Theiler J, Pommert KBJ, Krause TB, Turner HL, Murin CD, Pallesen J, Davidson E, Ahmed R, Aman MJ, Bukreyev A, Burton DR, Crowe Jr. JE, Davis CW, Georgiou G, Krammer F, Kyratsous CA, Lai JR, Nykiforuk C, Pauly MH, Rijal P, Takada A, Townsend AR, Volchkov V, Walker LM, Wang CI, Zeitlin L, Doranz BJ, Ward AB, Korber B, Kobinger GP, Andersen KG, Kawaoka Y, Alter G, Chandran K, Dye JM
Cell (2018) 174 pp. 938-952.e13 [ DOI: doi:10.1016/j.cell.2018.07.033 Pubmed: 30096313 ]