Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8dpl
Q-score: 0.536
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2.1.1d5 light chain variable domain (11 kDa, Protein from Homo sapiens)
- 6d6 single-chain variable fragment (25 kDa, Protein from Mus musculus)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Structure of ebov gp in complex with 2.1.1d5 scfv and 6d6 scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2.1.1d5 heavy chain variable domain (13 kDa, Protein from Homo sapiens)
Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7uot
Q-score: 0.559
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ DOI: doi:10.1126/scitranslmed.abq0991 Pubmed: 36288283 ]
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- Native lassa glycoprotein in complex with 8.9f-scfv and 37.2d-scfv (Complex)
- 8.9f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
- 8.9f heavy chain (variable domain) (15 kDa, Protein from Homo sapiens)
Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7uov
Q-score: 0.541
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ DOI: doi:10.1126/scitranslmed.abq0991 Pubmed: 36288283 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 12.1f heavy chain (variable domain) (12 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- 12.1f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- Native lassa glycoprotein in complex with 12.1f-scfv and 37.2d-scfv (Complex)
Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7tyv
Q-score: 0.447
Enriquez AS, Buck TK, Li H, Norris MJ, Moon-Walker A, Zandonatti MA, Harkins SS, Robinson JE, Branco LM, Garry RF, Saphire EO, Hastie KM
Cell Rep (2022) 39 pp. 110841-110841 [ Pubmed: 35613585 DOI: doi:10.1016/j.celrep.2022.110841 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lassa virus glycoprotein josiah (Complex from Lassa virus)
- Lassa virus josiah gp complexed with anti-lassa virus antibody fab fragment 25.10c (350 kDa, Complex)
- 25.10c fab fragment (Complex from Homo sapiens)
- 25.10c fab heavy chain (24 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
- 25.10c fab light chain (25 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (19 kDa, Protein from Lassa virus)