Human cap-dependent 48S pre-initiation complex
Resolution: 6.3 Å
EM Method: Single-particle
Fitted PDBs: 6fec
Q-score: 0.116
Eliseev B, Yeramala L, Leitner A, Karuppasamy M, Raimondeau E, Huard K, Alkalaeva E, Aebersold R, Schaffitzel C
Nucleic Acids Res (2018) 46 pp. 2678-2689 [ Pubmed: 29401259 DOI: doi:10.1093/nar/gky054 ]
- 18s ribosomal rna (572 kDa, RNA from Homo sapiens)
- Eukaryotic translation initiation factor 2 beta subunit (eif2-beta) (2 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s9 (21 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s5 (21 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 1 (30 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 4b (Complex from Homo sapiens)
- Ubiquitin-40s ribosomal protein s27a (8 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (15 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit d (42 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (8 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 3 (45 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (27 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (23 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (23 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (21 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (16 kDa, Protein from Homo sapiens)
- Messenger rna (26-mer) (8 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s3a (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit c (97 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (11 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 4b (72 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Eukaryotic translation initiation factor 3 subunit e (52 kDa, Protein from Homo sapiens)
- Mrna (Complex from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit f (37 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (25 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s12 (13 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit k (25 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit a (164 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit l (66 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (34 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- Transfer rna (75-mer) (24 kDa, RNA from Homo sapiens)
- Human cap-dependent 48s translation pre-initiation complex (2 MDa, Complex)
- Eukaryotic translation initiation factor 3 subunit h (39 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s20 (11 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (11 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit b (124 kDa, Protein from Homo sapiens)
- Human cap-dependent 48s translation pre-initiation complex (Complex from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit m (42 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (8 kDa, Protein from Homo sapiens)
Human cap-dependent 48S pre-initiation complex
Eliseev B, Yeramala L, Leitner A, Karuppasamy M, Raimondeau E, Huard K, Alkalaeva E, Aebersold R, Schaffitzel C
Nucleic Acids Res (2018) [ Pubmed: 29401259 DOI: doi:10.1093/nar/gky054 ]
Cryo-EM Structure of Saccharomyces cerevisiae Target of Rapamycin Complex 2
Resolution: 7.9 Å
EM Method: Single-particle
Fitted PDBs: 6emk
Q-score: 0.145
Karuppasamy M, Kusmider B, Oliveira TM, Gaubitz C, Prouteau M, Loewith R, Schaffitzel C
Nat Commun (2017) 8 pp. 1729-1729 [ DOI: doi:10.1038/s41467-017-01862-0 Pubmed: 29170376 ]
- Target of rapamycin complex 2 subunit avo1 (131 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Target of rapamycin complex 2 subunit avo2 (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Serine/threonine-protein kinase tor2 (281 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Target of rapamycin protein complex 2 (1 MDa, Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Target of rapamycin complex subunit lst8 (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Target of rapamycin complex 2 subunit tsc11 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
cryoEM structure of bacterial holo-translocon
Resolution: 14.0 Å
EM Method: Single-particle
Fitted PDBs: 5mg3
Q-score: 0.034
Botte M, Zaccai NR, Nijeholt JL, Martin R, Knoops K, Papai G, Zou J, Deniaud A, Karuppasamy M, Jiang Q, Roy AS, Schulten K, Schultz P, Rappsilber J, Zaccai G, Berger I, Collinson I, Schaffitzel C
Sci Rep (2016) 6 pp. 38399-38399 [ DOI: doi:10.1038/srep38399 Pubmed: 27924919 ]
- Membrane protein insertase yidc (62 kDa, Protein from Escherichia coli)
- Protein translocase subunit secf (35 kDa, Protein from Escherichia coli)
- Protein-export membrane protein secg (14 kDa, Protein from Escherichia coli)
- Protein translocase subunit sece (15 kDa, Protein from Escherichia coli)
- Bacterial holo-translocon (htl) (250 kDa, Complex from Escherichia coli)
- Protein translocase subunit secy (50 kDa, Protein from Escherichia coli)
- Protein translocase subunit secd (67 kDa, Protein from Escherichia coli)
Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C
Nucleic Acids Res (2015) 43 pp. 7600-7611 [ Pubmed: 26130714 DOI: doi:10.1093/nar/gkv668 ]
- Complex of four proteins: smg1, smg8, smg9 and upf1 (720 kDa, Sample)
- Upf1 (130 kDa, Protein from Homo sapiens)
- Smg-1 (420 kDa, Protein from Homo sapiens)
- Smg-8 (110 kDa, Protein from Homo sapiens)
- Smg-9 (60 kDa, Protein from Homo sapiens)
Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C
Nucleic Acids Res (2015) 43 pp. 7600-7611 [ Pubmed: 26130714 DOI: doi:10.1093/nar/gkv668 ]
- Complex of four proteins: smg1, smg8, smg9 and upf1 (720 kDa, Sample)
- Upf1 (130 kDa, Protein from Homo sapiens)
- Smg-1 (420 kDa, Protein from Homo sapiens)
- Smg-8 (110 kDa, Protein from Homo sapiens)
- Smg-9 (60 kDa, Protein from Homo sapiens)
Structure of Target Of Rapapmycin Complex 2 (TORC2) from Saccharomyces cerevisiae
Gaubitz C, Oliveira TM, Prouteau M, Leitner A, Karuppasamy M, Konstantinidou G, Rispal D, Eltschinger S, Robinson GC, Thore S, Aebersold R, Schaffitzel C, Loewith R
Mol Cell (2015) 58 pp. 977-988 [ DOI: doi:10.1016/j.molcel.2015.04.031 Pubmed: 26028537 ]
- Yeast torc2 (1 MDa, Protein from Saccharomyces cerevisiae)
- Yeast target of rapamycin complex 2 (1 MDa, Sample)
EM structure of ribosome-SRP-FtsY complex in "closed" state
Resolution: 5.7 Å
EM Method: Single-particle
Fitted PDBs: 5aka
Q-score: 0.156
von Loeffelholz O, Jiang Q, Ariosa A, Karuppasamy M, Huard K, Berger I, Shan SO, Schaffitzel C
PNAS (2015) 112 pp. 3943-3948 [ DOI: doi:10.1073/pnas.1424453112 Pubmed: 25775537 ]
Structural Basis of Signal Sequence Surveillance and Selection by the SRP-SR Complex
Resolution: 12.0 Å
EM Method: Single-particle
Fitted PDBs: 3zn8
Q-score: 0.042
von Loeffelholz O, Knoops K, Ariosa A, Zhang X, Karuppasamy M, Huard K, Schoehn G, Berger I, Shan SO, Schaffitzel C
Nat Struct Mol Biol (2013) 20 pp. 604-610 [ Pubmed: 23563142 DOI: doi:10.1038/nsmb.2546 ]
- Signal recognition particle protein (Protein from Escherichia coli)
- 4.5 s rna (Protein from Escherichia coli)
- Signal recognition particle receptor ftsy (145 kDa, Protein from Escherichia coli)
- Signal recognition particle 54 kda protein (Protein from Sulfolobus solfataricus)
- 70s ribosome (2 MDa, Complex from Escherichia coli)
- Dipeptidyl aminopeptidase b (Protein from Saccharomyces cerevisiae)
- Ribosome-srp-ftsy complex with espp nascent chain (2 MDa, Sample)