10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8f9m
Q-score: 0.346
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ Pubmed: 38753770 DOI: doi:10.1126/science.adk0582 ]
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized wild type mice, and nhp monoclonal fab rm20a3 (Complex from Mus musculus)
- V3-glycan epitope polyclonal fab light chain (9 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V3-glycan epitope polyclonal fab heavy chain (9 kDa, Protein from Mus musculus)
HIV Env BG505_MD39_B16 SOSIP boosting trimer in complex with B16_d77.5 mouse Fab and RM20A3 Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vfv
Q-score: 0.495
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ Pubmed: 38753770 DOI: doi:10.1126/science.adk0582 ]
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- B16_d77.5 mouse fab heavy chain fv (13 kDa, Protein from Mus musculus)
- Iv env bg505_md39_b16 sosip boosting trimer in complex with b16_d77.5 mouse fab and rm20a3 fab (Complex from Human immunodeficiency virus 1)
- B16_d77.5 mouse fab light chain fv (12 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8t4d
Q-score: 0.509
Steichen JM, Phung I, Salcedo E, Ozorowski G, Willis JR, Baboo S, Liguori A, Cottrell CA, Torres JL, Madden PJ, Ma KM, Sutton HJ, Lee JH, Kalyuzhniy O, Allen JD, Rodriguez OL, Adachi Y, Mullen TM, Georgeson E, Kubitz M, Burns A, Barman S, Mopuri R, Metz A, Altheide TK, Diedrich JK, Saha S, Shields K, Schultze SE, Smith ML, Schiffner T, Burton DR, Watson CT, Bosinger SE, Crispin M, Yates 3rd JR, Paulson JC, Ward AB, Sok D, Crotty S, Schief WR
Science (2024) 384 pp. eadj8321-eadj8321 [ Pubmed: 38753769 DOI: doi:10.1126/science.adj8321 ]
- Md65 n332-gt5 sosip in complex with rm_n332_08 fab and rm20a3 fab (Complex from Macaca mulatta)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Rm_n332_08 light chain fv (12 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm_n332_08 heavy chain fv (14 kDa, Protein from Macaca mulatta)
MD65 N332-GT5 SOSIP in complex with RM_N332_07 Fab and RM20A3 Fab
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8t4l
Q-score: 0.476
Steichen JM, Phung I, Salcedo E, Ozorowski G, Willis JR, Baboo S, Liguori A, Cottrell CA, Torres JL, Madden PJ, Ma KM, Sutton HJ, Lee JH, Kalyuzhniy O, Allen JD, Rodriguez OL, Adachi Y, Mullen TM, Georgeson E, Kubitz M, Burns A, Barman S, Mopuri R, Metz A, Altheide TK, Diedrich JK, Saha S, Shields K, Schultze SE, Smith ML, Schiffner T, Burton DR, Watson CT, Bosinger SE, Crispin M, Yates 3rd JR, Paulson JC, Ward AB, Sok D, Crotty S, Schief WR
Science (2024) 384 pp. eadj8321-eadj8321 [ Pubmed: 38753769 DOI: doi:10.1126/science.adj8321 ]
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Rm_n332_07 light chain fv (11 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip in complex with rm_n332_07 fab and rm20a3 fab (Complex from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm_n332_07 heavy chain fv (14 kDa, Protein from Macaca mulatta)