10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8f9m
Q-score: 0.346
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ Pubmed: 38753770 DOI: doi:10.1126/science.adk0582 ]
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized wild type mice, and nhp monoclonal fab rm20a3 (Complex from Mus musculus)
- V3-glycan epitope polyclonal fab light chain (9 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V3-glycan epitope polyclonal fab heavy chain (9 kDa, Protein from Mus musculus)
HIV-1 Envelope ApexGT2.2MUT in complex with PCT64.LMCA Fab
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7t73
Q-score: 0.388
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ Pubmed: 36179689 DOI: doi:10.1016/j.immuni.2022.09.001 ]
- Hiv envelope apexgt2.2mut gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Pct64.lmca fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pct64.lmca fab heavy chain (25 kDa, Protein from Homo sapiens)
- Hiv envelope apexgt2.2mut gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope apexgt2.2mut in complex with pct64.lmca fab (Complex from Human immunodeficiency virus 1)
HIV-1 Envelope ApexGT3 in complex with PG9.iGL Fab
Resolution: 4.43 Å
EM Method: Single-particle
Fitted PDBs: 7t76
Q-score: 0.324
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ Pubmed: 36179689 DOI: doi:10.1016/j.immuni.2022.09.001 ]
- Pg9.igl fab heavy chain (28 kDa, Protein from Homo sapiens)
- Hiv envelope apexgt3 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv envelope apexgt3 gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope apexgt3 in complex with pg9.igl fab (Complex from Human immunodeficiency virus 1)
- Pg9.igl fab light chain (28 kDa, Protein from Homo sapiens)
HIV-1 Envelope ApexGT3.N130 in complex with PG9 Fab
Resolution: 4.75 Å
EM Method: Single-particle
Fitted PDBs: 7t77
Q-score: 0.282
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ Pubmed: 36179689 DOI: doi:10.1016/j.immuni.2022.09.001 ]
- Hiv envelope apexgt3.n130 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 envelope apexgt3.n130 in complex with pg9 fab (Complex from Human immunodeficiency virus 1)
- Pg9 fab heavy chain (27 kDa, Protein from Homo sapiens)
- Pg9 fab light chain (22 kDa, Protein from Homo sapiens)
- Hiv envelope apexgt3.n130 gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
BG505 SOSIP MD39 in complex with the polyclonal Fab pAbC-4 from animal Rh.33104 (Wk26 time point)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7l8d
Q-score: 0.318
Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Pena AT, Rocha RF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB
Nat Commun (2021) 12 pp. 4817-4817 [ Pubmed: 34376662 DOI: doi:10.1038/s41467-021-25087-4 ]
- Bg505 sosip md39 - gp41 (16 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip md39 - gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Rh.33104 pabc-3 - light chain (8 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip md39 in complex with the polyclonal fab pabc-4 from animal rh.33104 (wk26 time point) (Complex from Human immunodeficiency virus 1)
- Rh.33104 pabc-3 - heavy chain (9 kDa, Protein from Macaca mulatta)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7l8e
Q-score: 0.362
Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Pena AT, Rocha RF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB
Nat Commun (2021) 12 pp. 4817-4817 [ Pubmed: 34376662 DOI: doi:10.1038/s41467-021-25087-4 ]
- Rh.33172 pabc-1 heavy chain, rh.33172 pabc-1 light chain (Complex from Macaca mulatta)
- Envelope glycoprotein gp160 (74 kDa, Protein from Human immunodeficiency virus 1)
- Rh.33172 pabc-1 light chain (8 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2(7s) in complex with the polyclonal fab pabc-1 from animal rh.33172 (wk38 time point) (Complex)
- Envelope glycoprotein gp160 (Complex from Human immunodeficiency virus 1)
- Rh.33172 pabc-1 heavy chain (9 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7l8g
Q-score: 0.361
Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Pena AT, Rocha RF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB
Nat Commun (2021) 12 pp. 4817-4817 [ Pubmed: 34376662 DOI: doi:10.1038/s41467-021-25087-4 ]
- Bg505 sosip.v5.2(7s) in complex with the polyclonal fab pabc-3 from animal rh.33172 (wk38 time point) (Complex)
- Rh.33172 pabc-3 heavy chain (9 kDa, Protein from Macaca mulatta)
- Rh.33172 pabc-3 heavy chain, rh.33172 pabc-3 light chain (Complex from Macaca mulatta)
- Envelope glycoprotein gp160 (74 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rh.33172 pabc-3 light chain (8 kDa, Protein from Macaca mulatta)
Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Pena AT, Rocha RF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB
Nat Commun (2021) 12 pp. 4817-4817 [ Pubmed: 34376662 DOI: doi:10.1038/s41467-021-25087-4 ]
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7l8s
Q-score: 0.355
Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Pena AT, Rocha RF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB
Nat Commun (2021) 12 pp. 4817-4817 [ DOI: doi:10.1038/s41467-021-25087-4 Pubmed: 34376662 ]
- Rh.33172 pabc-4 - light chain (8 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2(7s) - gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Rh.33172 pabc-4 - heavy chain (9 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2(7s) in complex with the polyclonal fab pabc-4 from animal rh.33172 (wk38 time point) (Complex)
- Polyclonal fab pabc-4 from animal rh.33172 (Complex from Macaca mulatta)
- Bg505 sosip.v5.2(7s) - gp41 (16 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip.v5.2(7s) (Complex from Human immunodeficiency virus 1)