10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
HIV-1 Envelope ApexGT2.2MUT in complex with PCT64.LMCA Fab
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7t73
Q-score: 0.388
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ Pubmed: 36179689 DOI: doi:10.1016/j.immuni.2022.09.001 ]
- Hiv envelope apexgt2.2mut gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Pct64.lmca fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pct64.lmca fab heavy chain (25 kDa, Protein from Homo sapiens)
- Hiv envelope apexgt2.2mut gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope apexgt2.2mut in complex with pct64.lmca fab (Complex from Human immunodeficiency virus 1)
HIV-1 Envelope ApexGT3 in complex with PG9.iGL Fab
Resolution: 4.43 Å
EM Method: Single-particle
Fitted PDBs: 7t76
Q-score: 0.324
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ Pubmed: 36179689 DOI: doi:10.1016/j.immuni.2022.09.001 ]
- Pg9.igl fab heavy chain (28 kDa, Protein from Homo sapiens)
- Hiv envelope apexgt3 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv envelope apexgt3 gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope apexgt3 in complex with pg9.igl fab (Complex from Human immunodeficiency virus 1)
- Pg9.igl fab light chain (28 kDa, Protein from Homo sapiens)
HIV-1 Envelope ApexGT3.N130 in complex with PG9 Fab
Resolution: 4.75 Å
EM Method: Single-particle
Fitted PDBs: 7t77
Q-score: 0.282
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ Pubmed: 36179689 DOI: doi:10.1016/j.immuni.2022.09.001 ]
- Hiv envelope apexgt3.n130 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 envelope apexgt3.n130 in complex with pg9 fab (Complex from Human immunodeficiency virus 1)
- Pg9 fab heavy chain (27 kDa, Protein from Homo sapiens)
- Pg9 fab light chain (22 kDa, Protein from Homo sapiens)
- Hiv envelope apexgt3.n130 gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 6dfg
Q-score: 0.348
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Mature bg18 fragment antigen binding heavy chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 md39 sosip trimer in complex with mature bg18 fragment antigen binding (570 kDa, Complex)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Mature bg18 fragment antigen binding light chain (22 kDa, Protein from Homo sapiens)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
- Bg18 fragment (Complex from Homo sapiens)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)