Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8f9g
Q-score: 0.446
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ Pubmed: 38753770 DOI: doi:10.1126/science.adk0582 ]
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized bg18hcgl knock-in mice v3-glycan epitope polyclonal fab heavy chain (Complex from Mus musculus)
- V3-glycan epitope polyclonal fab light chain (8 kDa, Protein from Mus musculus)
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V3-glycan epitope polyclonal fab heavy chain (10 kDa, Protein from Mus musculus)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8f9m
Q-score: 0.346
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ Pubmed: 38753770 DOI: doi:10.1126/science.adk0582 ]
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized wild type mice, and nhp monoclonal fab rm20a3 (Complex from Mus musculus)
- V3-glycan epitope polyclonal fab light chain (9 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V3-glycan epitope polyclonal fab heavy chain (9 kDa, Protein from Mus musculus)
BG505 SOSIP reconstructed from a designed tetrahedral nanoparticle, BG505 SOSIP-T33_dn2
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6vl5
Q-score: 0.333
Martin JT, Cottrell CA, Antanasijevic A, Carnathan DG, Cossette BJ, Enemuo CA, Gebru EH, Choe Y, Viviano F, Fischinger S, Tokatlian T, Cirelli KM, Ueda G, Copps J, Schiffner T, Menis S, Alter G, Schief WR, Crotty S, King NP, Baker D, Silvestri G, Ward AB, Irvine DJ
NPJ Vaccines (2020) 5 pp. 72-72 [ Pubmed: 32802411 DOI: doi:10.1038/s41541-020-00223-1 ]
- Bg505 sosip.v5.2(7s) - gp41 (18 kDa, Protein from synthetic construct)
- Bg505 sosip trimer reconstructed from a designed tetrahedral nanoparticle bg505 sosip-t33_dn2 (Complex from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip.v5.2(7s) - gp120 (56 kDa, Protein from synthetic construct)
De novo designed tetrahedral nanoparticle T33_dn2 presenting BG505 SOSIP trimers
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 6vl6
Q-score: 0.252
Martin JT, Cottrell CA, Antanasijevic A, Carnathan DG, Cossette BJ, Enemuo CA, Gebru EH, Choe Y, Viviano F, Fischinger S, Tokatlian T, Cirelli KM, Ueda G, Copps J, Schiffner T, Menis S, Alter G, Schief WR, Crotty S, King NP, Baker D, Silvestri G, Ward AB, Irvine DJ
NPJ Vaccines (2020) 5 pp. 72-72 [ Pubmed: 32802411 DOI: doi:10.1038/s41541-020-00223-1 ]
- T33_dn2a (14 kDa, Protein from synthetic construct)
- T33_dn2b (14 kDa, Protein from synthetic construct)
- De novo designed tetrahedral nanoparticle bg505 sosip-t33_dn2 (Complex from synthetic construct)