3.0 A resolution structure of a DNA-loaded MCM double hexamer
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7p30
Q-score: 0.538
Greiwe JF, Miller TCR, Locke J, Martino F, Howell S, Schreiber A, Nans A, Diffley JFX, Costa A
Nat Struct Mol Biol (2022) 29 pp. 10-20 [ DOI: doi:10.1038/s41594-021-00698-z Pubmed: 34963704 ]
- S. cerevisiae mcm double hexamer bound to duplex dna (Complex from Saccharomyces cerevisiae S288C)
- Dna (53-mer) (16 kDa, DNA from Saccharomyces cerevisiae S288C)
- Dna (53-mer) (16 kDa, DNA from Saccharomyces cerevisiae S288C)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna replication licensing factor mcm3 (111 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Structure of a DNA-loaded MCM double hexamer engaged with the Dbf4-dependent kinase
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7p5z
Q-score: 0.451
Greiwe JF, Miller TCR, Locke J, Martino F, Howell S, Schreiber A, Nans A, Diffley JFX, Costa A
Nat Struct Mol Biol (2022) 29 pp. 10-20 [ DOI: doi:10.1038/s41594-021-00698-z Pubmed: 34963704 ]
- Cell division control protein 7 (58 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ddk kinase regulatory subunit dbf4 (84 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna (53-mer) (16 kDa, DNA from Saccharomyces cerevisiae S288C)
- Dna (53-mer) (16 kDa, DNA from Saccharomyces cerevisiae S288C)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna replication licensing factor mcm3 (111 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-loaded mcm double hexamer engaged with the dimeric dbf4-dependent kinase (Complex from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Electron cryo-microscopy of CSN-SCF-N8 complex
Mosadeghi R, Reichermeier KM, Winkler M, Schreiber A, Reitsma JM, Zhang Y, Stengel F, Cao J, Kim M, Sweredoski MJ, Hess S, Leitner A, Aebersold R, Peter M, Deshaies RJ, Enchev RI
eLife (2016) 5 [ Pubmed: 27031283 DOI: doi:10.7554/eLife.12102 ]
- Csn1 (55 kDa, Protein from Homo sapiens)
- Csn5h138a-n8_scf/skp2 (500 kDa, Sample)
- Cul1 (89 kDa, Protein from Homo sapiens)
- Csn5 (37 kDa, Protein from Homo sapiens)
- Rbx1 (12 kDa, Protein from Homo sapiens)
- Csn7b (29 kDa, Protein from Homo sapiens)
- Skp1 (Protein from Homo sapiens)
- Csn3 (47 kDa, Protein from Homo sapiens)
- Csn6 (36 kDa, Protein from Homo sapiens)
- Skp2 (Protein from Homo sapiens)
- Csn2 (51 kDa, Protein from Homo sapiens)
- Csn8 (23 kDa, Protein from Homo sapiens)
- Cks1 (9 kDa, Protein from Homo sapiens)
- Nedd8 (9 kDa, Protein from Homo sapiens)
- Csn4 (46 kDa, Protein from Homo sapiens)
Negative stain electron microscopy of a CSN-SCF~Nedd8/Skp2/Cks1 complex
Enchev RI, Scott DC, da Fonseca PC, Schreiber A, Monda JK, Schulman BA, Peter M, Morris EP
Cell Rep (2012) 2 pp. 616-627 [ DOI: doi:10.1016/j.celrep.2012.08.019 Pubmed: 22959436 ]
- Nedd8 (9 kDa, Protein from Homo sapiens)
- Csn1 (53 kDa, Protein from Homo sapiens)
- Skp2 (47 kDa, Protein from Homo sapiens)
- Rbx1 (12 kDa, Protein from Homo sapiens)
- Cks1 (10 kDa, Protein from Homo sapiens)
- Csn5 (40 kDa, Protein from Homo sapiens)
- Csn7b (30 kDa, Protein from Homo sapiens)
- Skp1 (19 kDa, Protein from Homo sapiens)
- Csn-scf~nedd8/skp2/cks1 (500 kDa, Sample)
- Csn6 (36 kDa, Protein from Homo sapiens)
- Csn2 (52 kDa, Protein from Homo sapiens)
- Cul1 (90 kDa, Protein from Homo sapiens)
- Csn4 (46 kDa, Protein from Homo sapiens)
- Csn8 (23 kDa, Protein from Homo sapiens)
- Csn3 (48 kDa, Protein from Homo sapiens)
Negative stain electron microscopy of a CSN-SCF~Nedd8/Fbw7 complex
Enchev RI, Scott DC, da Fonseca PC, Schreiber A, Monda JK, Schulman BA, Peter M, Morris EP
Cell Rep (2012) 2 pp. 616-627 [ DOI: doi:10.1016/j.celrep.2012.08.019 Pubmed: 22959436 ]
- Fbw7 (47 kDa, Protein from Homo sapiens)
- Csn1 (53 kDa, Protein from Homo sapiens)
- Nedd8 (9 kDa, Protein from Homo sapiens)
- Rbx1 (12 kDa, Protein from Homo sapiens)
- Csn5 (40 kDa, Protein from Homo sapiens)
- Csn7b (30 kDa, Protein from Homo sapiens)
- Skp1 (19 kDa, Protein from Homo sapiens)
- Csn6 (36 kDa, Protein from Homo sapiens)
- Csn2 (52 kDa, Protein from Homo sapiens)
- Csn-scf~nedd8/fbw7 (500 kDa, Sample)
- Cul1 (90 kDa, Protein from Homo sapiens)
- Csn4 (46 kDa, Protein from Homo sapiens)
- Csn8 (23 kDa, Protein from Homo sapiens)
- Csn3 (48 kDa, Protein from Homo sapiens)
Negative stain electron microscopy of a CSN(dCsn5)-SCF~Nedd8/Skp2/Cks1 complex
Enchev RI, Scott DC, da Fonseca PC, Schreiber A, Monda JK, Schulman BA, Peter M, Morris EP
Cell Rep (2012) 2 pp. 616-627 [ DOI: doi:10.1016/j.celrep.2012.08.019 Pubmed: 22959436 ]
- Nedd8 (9 kDa, Protein from Homo sapiens)
- Csn1 (53 kDa, Protein from Homo sapiens)
- Skp2 (47 kDa, Protein from Homo sapiens)
- Rbx1 (12 kDa, Protein from Homo sapiens)
- Cks1 (10 kDa, Protein from Homo sapiens)
- Csn7b (30 kDa, Protein from Homo sapiens)
- Csn(dcsn5)-scf~nedd8/skp2/cks1 (500 kDa, Sample)
- Skp1 (19 kDa, Protein from Homo sapiens)
- Csn6 (36 kDa, Protein from Homo sapiens)
- Csn2 (52 kDa, Protein from Homo sapiens)
- Cul1 (90 kDa, Protein from Homo sapiens)
- Csn4 (46 kDa, Protein from Homo sapiens)
- Csn8 (23 kDa, Protein from Homo sapiens)
- Csn3 (48 kDa, Protein from Homo sapiens)
Negative stain electron microscopy of a CSN complex
Enchev RI, Scott DC, da Fonseca PC, Schreiber A, Monda JK, Schulman BA, Peter M, Morris EP
Cell Rep (2012) 2 pp. 616-627 [ DOI: doi:10.1016/j.celrep.2012.08.019 Pubmed: 22959436 ]
- Csn (320 kDa, Sample)
- Csn1 (53 kDa, Protein from Homo sapiens)
- Csn5 (40 kDa, Protein from Homo sapiens)
- Csn7b (30 kDa, Protein from Homo sapiens)
- Csn6 (36 kDa, Protein from Homo sapiens)
- Csn2 (52 kDa, Protein from Homo sapiens)
- Csn4 (46 kDa, Protein from Homo sapiens)
- Csn8 (23 kDa, Protein from Homo sapiens)
- Csn3 (48 kDa, Protein from Homo sapiens)
Negative stain electron microscopy of a CSN complex
Enchev RI, Scott DC, da Fonseca PC, Schreiber A, Monda JK, Schulman BA, Peter M, Morris EP
Cell Rep (2012) 2 pp. 616-627 [ DOI: doi:10.1016/j.celrep.2012.08.019 Pubmed: 22959436 ]
- Csn1 (53 kDa, Protein from Homo sapiens)
- Csn5 (40 kDa, Protein from Homo sapiens)
- Csn7b (30 kDa, Protein from Homo sapiens)
- Csn6 (36 kDa, Protein from Homo sapiens)
- Csn2 (52 kDa, Protein from Homo sapiens)
- Csn(csn2dn1-269) (290 kDa, Sample)
- Csn4 (46 kDa, Protein from Homo sapiens)
- Csn8 (23 kDa, Protein from Homo sapiens)
- Csn3 (48 kDa, Protein from Homo sapiens)
Structural basis for the subunit assembly of the anaphase promoting complex
Schreiber A, Stengel F, Zhang Z, Enchev RI, Kong EH, Morris EP, Robinson CV, da Fonseca PC, Barford D
Nature (2011) 470 pp. 227-232 [ Pubmed: 21307936 DOI: doi:10.1038/nature09756 ]
Structural basis for the subunit assembly of the anaphase promoting complex
Schreiber A, Stengel F, Zhang Z, Enchev RI, Kong EH, Morris EP, Robinson CV, da Fonseca PC, Barford D
Nature (2011) 470 pp. 227-232 [ Pubmed: 21307936 DOI: doi:10.1038/nature09756 ]
- Apc4_5 (Protein from Saccharomyces cerevisiae)
- Apc4-apc5 heterodimer (155 kDa, Sample)