Human calcium-sensing receptor bound with cinacalcet in detergent
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wpg
Q-score: 0.541
Ling S, Meng X, Zhang Y, Xia Z, Zhou Y, Yang F, Shi P, Shi C, Tian C
Cell Res (2024) 34 pp. 169-172 [ Pubmed: 37919470 DOI: doi:10.1038/s41422-023-00892-2 ]
- Tryptophan (204 Da, Ligand)
- Calcium sensing receptor dimer (Complex from Homo sapiens)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8wpu
Q-score: 0.49
Ling S, Meng X, Zhang Y, Xia Z, Zhou Y, Yang F, Shi P, Shi C, Tian C
Cell Res (2024) 34 pp. 169-172 [ Pubmed: 37919470 DOI: doi:10.1038/s41422-023-00892-2 ]
- G subunit q (gi2-mini-gq chimeric) (28 kDa, Protein from Homo sapiens)
- Casr-gq complex (Complex from Homo sapiens)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- Extracellular calcium-sensing receptor,calcium-sensing receptor (120 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- Scfv16 (31 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
Cryo-EM structure of Apo-alpha-syn fibril
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 7yk2
Q-score: 0.538
Zhang S, Li J, Xu Q, Xia W, Tao Y, Shi C, Li D, Xiang S, Liu C
J Am Chem Soc (2023) 145 pp. 4473-4484 [ DOI: doi:10.1021/jacs.2c10854 Pubmed: 36794997 ]
- Cryo-em structure of apo-alpha-syn fibril (Cellular component from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo-EM structure of dLAG3-alpha-syn fibril
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 7yk8
Q-score: 0.586
Zhang S, Li J, Xu Q, Xia W, Tao Y, Shi C, Li D, Xiang S, Liu C
J Am Chem Soc (2023) 145 pp. 4473-4484 [ DOI: doi:10.1021/jacs.2c10854 Pubmed: 36794997 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Cryo-em structure of dlag3-alpha-syn fibril (Cellular component from Homo sapiens)
Human Calcium-Sensing Receptor bound with calcium ions
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7dtt
Q-score: 0.442
Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C
Cell Res (2021) 31 pp. 383-394 [ DOI: doi:10.1038/s41422-021-00474-0 Pubmed: 33603117 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Full-lenth human calcium-sensing receptor bound with 20 mm calcium ions (Complex from Homo sapiens)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Human Calcium-Sensing Receptor bound with L-Trp
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7dtu
Q-score: 0.339
Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C
Cell Res (2021) 31 pp. 383-394 [ DOI: doi:10.1038/s41422-021-00474-0 Pubmed: 33603117 ]
- Tryptophan (204 Da, Ligand)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human calcium-sensing receptor bound with l-trp (Complex from Homo sapiens)
Human Calcium-Sensing Receptor bound with L-Trp and calcium ions
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7dtv
Q-score: 0.483
Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C
Cell Res (2021) 31 pp. 383-394 [ DOI: doi:10.1038/s41422-021-00474-0 Pubmed: 33603117 ]
- Human calcium-sensing receptor bound with l-trp and calcium ions (Complex from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
Human Calcium-Sensing Receptor in the inactive close-close conformation
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7dtw
Q-score: 0.306
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7cal
Q-score: 0.532
Li S, Yang F, Sun D, Zhang Y, Zhang M, Liu S, Zhou P, Shi C, Zhang L, Tian C
Cell Res (2020) 30 pp. 1049-1052 [ DOI: doi:10.1038/s41422-020-00407-3 Pubmed: 32901112 ]
- 1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
- Potassium channel kat1 (78 kDa, Protein from Arabidopsis thaliana)
- Kat1 (Complex from Arabidopsis thaliana)