Cryo-EM structure of Antibody SKT05 in complex with Western Equine Encephalitis Virus-like Particle
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
Cryo-EM I1 reconstruction of antibody SKV16 in complex with VEEV alphavirus VLP
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
Resolution: 5.84 Å
EM Method: Single-particle
Fitted PDBs: 8dun
Q-score: 0.214
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
- Antibody skw11 light chain (23 kDa, Protein from Macaca fascicularis)
- Spike glycoprotein e1 (52 kDa, Protein from Western equine encephalitis virus)
- Antibody skw11 heavy chain (24 kDa, Protein from Macaca fascicularis)
- Spike glycoprotein e2 (45 kDa, Protein from Western equine encephalitis virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Western equine encephalitis virus trimer in complex with antibody fab skw11 (Complex from Western equine encephalitis virus)
Locally refined region of SARS-CoV-2 spike in complex with antibody A19-46.1
Resolution: 5.08 Å
EM Method: Single-particle
Fitted PDBs: 7tc9
Q-score: 0.221
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Homo sapiens)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibody a19-46.1, local refinement. (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 5w9n
Q-score: 0.214
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- Mers s (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vh (25 kDa, Protein from Mus musculus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)