Structure of KRAS G12V/HLA-A*03:01 in complex with antibody fragment V2
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7stf
Q-score: 0.393
Wright KM, DiNapoli SR, Miller MS, Aitana Azurmendi P, Zhao X, Yu Z, Chakrabarti M, Shi W, Douglass J, Hwang MS, Hsiue EH, Mog BJ, Pearlman AH, Paul S, Konig MF, Pardoll DM, Bettegowda C, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Gabelli SB
Nat Commun (2023) 14 pp. 5063-5063 [ Pubmed: 37604828 DOI: doi:10.1038/s41467-023-40821-w ]
- Hla class i histocompatibility antigen, a alpha chain (32 kDa, Protein from Homo sapiens)
- Kras g12v (7-16) (885 Da, Protein from synthetic construct)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- Ternary complex of antibody-fragment v2 with kras g12v/hla-a*03:01 (Complex)
- Igg, fab light chain v2 (23 kDa, Protein from Homo sapiens)
- Igg, fab heavy chain v2 (23 kDa, Protein from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6xh7
Q-score: 0.344
Shi W, Zhang B, Jiang Y, Liu C, Zhou W, Chen M, Yang Y, Hu Y, Liu B
iScience (2021) 24 pp. 102449-102449 [ Pubmed: 34113812 DOI: doi:10.1016/j.isci.2021.102449 ]
- Dna-directed rna polymerase subunit beta' (155 kDa, Protein from Escherichia coli)
- Hth-type transcriptional regulator cuer (16 kDa, Protein from Escherichia coli)
- Nontemplate strand dna (54-mer) (16 kDa, DNA from Escherichia coli)
- Template strand dna (54-mer) (16 kDa, DNA from Escherichia coli)
- Copper (ii) ion (63 Da, Ligand)
- Dna-directed rna polymerase subunit omega (10 kDa, Protein from Escherichia coli)
- Dna-directed rna polymerase subunit alpha (36 kDa, Protein from Escherichia coli)
- Rna polymerase sigma factor rpod (72 kDa, Protein from Escherichia coli)
- Cuer-tac without rna (530 kDa, Complex from Escherichia coli)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerase subunit beta (150 kDa, Protein from Escherichia coli)
CueR-transcription activation complex with RNA transcript
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6xh8
Q-score: 0.318
Shi W, Zhang B, Jiang Y, Liu C, Zhou W, Chen M, Yang Y, Hu Y, Liu B
iScience (2021) 24 pp. 102449-102449 [ DOI: doi:10.1016/j.isci.2021.102449 Pubmed: 34113812 ]
- Dna-directed rna polymerase subunit beta' (155 kDa, Protein from Escherichia coli)
- Rna polymerase sigma factor rpod (72 kDa, Protein from Escherichia coli)
- Hth-type transcriptional regulator cuer (16 kDa, Protein from Escherichia coli)
- Dna-directed rna polymerase subunit omega (10 kDa, Protein from Escherichia coli)
- Nontemplate strand dna (54-mer) (16 kDa, DNA from Escherichia coli)
- Dna-directed rna polymerase subunit beta (150 kDa, Protein from Escherichia coli)
- Nascent rna (1 kDa, RNA from Escherichia coli)
- Zinc ion (65 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Dna-directed rna polymerase subunit alpha (36 kDa, Protein from Escherichia coli)
- Template strand dna (54-mer) (16 kDa, DNA from Escherichia coli)
- Cuer-tac with rna (540 kDa, Complex from Escherichia coli)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 5w9h
Q-score: 0.313
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- G4 vl (23 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mers s (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vh (25 kDa, Protein from Mus musculus)
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5w9i
Q-score: 0.414
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- Spike glycoprotein (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vl (23 kDa, Protein from Mus musculus)
- G4 vh (25 kDa, Protein from Mus musculus)
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 5w9j
Q-score: 0.237
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- G4 vh (25 kDa, Protein from Mus musculus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 5w9k
Q-score: 0.242
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- G4 vh (25 kDa, Protein from Mus musculus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 5w9l
Q-score: 0.237
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vh (25 kDa, Protein from Mus musculus)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 5w9m
Q-score: 0.252
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vh (25 kDa, Protein from Mus musculus)
MERS S ectodomain trimer in complex with Fab of neutralizing antibody G4
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 5w9n
Q-score: 0.214
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS
PNAS (2017) 114 pp. E7348-E7357 [ Pubmed: 28807998 DOI: doi:10.1073/pnas.1707304114 ]
- Mers s (146 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- G4 vh (25 kDa, Protein from Mus musculus)
- G4 vl (23 kDa, Protein from Mus musculus)
- Mers s ectodomain trimer in complex with fab of neutralizing antibody g4 (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)