Cryo-EM structure of the human BRISC dimer complex bound to compound FX-171-C
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8pvy
Q-score: 0.332
Chandler F, Reddy P, Bhutda S, Ross R, Walden M, Walker K, Cassel J, Prakesch M, Datti A, Campbell L, Foglizzo M, Bell L, Ault J, Al-awar R, Calabrese A, Sicheri F, Del Galdo F, Salvino J, Greenberg R, Zeqiraj E
To Be Published
- Lys-63-specific deubiquitinase brcc36 (35 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- N-[(1r,5s)-3-azabicyclo[3.1.0]hexan-6-yl]-1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]pyrazole-3-carboxamide (553 Da, Ligand)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 2 (43 kDa, Protein from Homo sapiens)
- Brisc dimer in complex with inhibitor fx-171-c (654 kDa, Complex from Homo sapiens)
- Brisc and brca1-a complex member 1 (29 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8py2
Q-score: 0.281
Chandler F, Reddy P, Bhutda S, Ross R, Walden M, Walker K, Cassel J, Prakesch M, Campbell L, Foglizzo M, Bell L, Ault J, Al-awar R, Calabrese A, Sicheri F, Del Galdo F, Salvino J, Greenberg R, Zeqiraj E
To Be Published
- Zinc ion (65 Da, Ligand)
- Brisc dimer in complex with inhibitor jms-175-2 (654 kDa, Complex from Homo sapiens)
- 1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]-n-piperidin-4-yl-pyrazole-3-carboxamide (555 Da, Ligand)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 2 (43 kDa, Protein from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (36 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 1 (29 kDa, Protein from Homo sapiens)
Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8bw9
Q-score: 0.468
Maisonneuve P, Sahmi M, Bergeron-Labrecque F, Ma XI, Queguiner J, Arseneault G, Lefrancois M, Kurinov I, Fronzes R, Sicheri F, Therrien M
Nat Struct Mol Biol (2024) 31 pp. 1028-1038 [ DOI: doi:10.1038/s41594-024-01233-6 Pubmed: 38388830 ]
- Trametinib (615 Da, Ligand)
- Quaternary complex of the kinase domains of ksr and mek bound to the scaffolding complex cnk-hyp (132 kDa, Complex from Drosophila melanogaster)
- Connector enhancer of ksr protein cnk (38 kDa, Protein from Drosophila melanogaster)
- Protein aveugle (13 kDa, Protein from Drosophila melanogaster)
- Dual specificity mitogen-activated protein kinase kinase dsor1 (43 kDa, Protein from Drosophila melanogaster)
- Ksr (36 kDa, Protein from Drosophila melanogaster)
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)