cryo-EM structure of a non-neutralizing antibody V3-21 in complex with SARS-CoV-2 spike
Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, Gonzalez-Dominguez I, Edgar JE, Bournazos S, Sun W, Carreno JM, Simon V, Ellebedy AH, Bajic G, Krammer F
Cell Rep (2024) 43 pp. 114922-114922 [ DOI: doi:10.1016/j.celrep.2024.114922 Pubmed: 39504245 ]
- Fab:spike complex (500 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
cryo-EM structure of a non-neutralizing antibody V6-12 in complex with SARS-CoV-2 spike
Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, Gonzalez-Dominguez I, Edgar JE, Bournazos S, Sun W, Carreno JM, Simon V, Ellebedy AH, Bajic G, Krammer F
Cell Rep (2024) 43 pp. 114922-114922 [ DOI: doi:10.1016/j.celrep.2024.114922 Pubmed: 39504245 ]
- Fab:spike complex (500 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8via
Q-score: 0.302
Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, Gonzalez-Dominguez I, Edgar JE, Bournazos S, Sun W, Carreno JM, Simon V, Ellebedy AH, Bajic G, Krammer F
Cell Rep (2024) 43 pp. 114922-114922 [ DOI: doi:10.1016/j.celrep.2024.114922 Pubmed: 39504245 ]
- Spike protein s1 (74 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pvi.v5-4 light chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with pvi.v5-4 fab (500 MDa, Complex from Homo sapiens)
- Pvi.v5-4 heavy chain (25 kDa, Protein from Homo sapiens)
- Spike protein s2 (62 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
S728-1157 IgG in complex with SARS-CoV-2-6P-Mut7 Spike protein (global refinement)
Changrob S, Halfmann PJ, Liu H, Torres JL, McGrath JJC, Ozorowski G, Li L, Wilbanks GD, Kuroda M, Maemura T, Huang M, Zheng NY, Turner HL, Erickson SA, Fu Y, Yasuhara A, Singh G, Monahan B, Mauldin J, Srivastava K, Simon V, Krammer F, Sather DN, Ward AB, Wilson IA, Kawaoka Y, Wilson PC
J Clin Inv (2023) 133 [ DOI: doi:10.1172/JCI166844 Pubmed: 36862518 ]
S728-1157 IgG in complex with SARS-CoV-2-6P-Mut7 Spike protein (focused refinement)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8d0z
Q-score: 0.42
Changrob S, Halfmann PJ, Liu H, Torres JL, McGrath JJC, Ozorowski G, Li L, Wilbanks GD, Kuroda M, Maemura T, Huang M, Zheng NY, Turner HL, Erickson SA, Fu Y, Yasuhara A, Singh G, Monahan B, Mauldin J, Srivastava K, Simon V, Krammer F, Sather DN, Ward AB, Wilson IA, Kawaoka Y, Wilson PC
J Clin Inv (2023) 133 [ DOI: doi:10.1172/JCI166844 Pubmed: 36862518 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S728-1157 fab heavy chain variable region (12 kDa, Protein from Homo sapiens)
- S728-1157 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- S728-1157 igg in complex with sars-cov-2-6p-mut7 s protein (Complex from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7l7f
Q-score: 0.517
Vogel AB, Kanevsky I, Che Y, Swanson KA, Muik A, Vormehr M, Kranz LM, Walzer KC, Hein S, Guler A, Loschko J, Maddur MS, Ota-Setlik A, Tompkins K, Cole J, Lui BG, Ziegenhals T, Plaschke A, Eisel D, Dany SC, Fesser S, Erbar S, Bates F, Schneider D, Jesionek B, Sanger B, Wallisch AK, Feuchter Y, Junginger H, Krumm SA, Heinen AP, Adams-Quack P, Schlereth J, Schille S, Kroner C, de la Caridad Guimil Garcia R, Hiller T, Fischer L, Sellers RS, Choudhary S, Gonzalez O, Vascotto F, Gutman MR, Fontenot JA, Hall-Ursone S, Brasky K, Griffor MC, Han S, Su AAH, Lees JA, Nedoma NL, Mashalidis EH, Sahasrabudhe PV, Tan CY, Pavliakova D, Singh G, Fontes-Garfias C, Pride M, Scully IL, Ciolino T, Obregon J, Gazi M, Carrion Jr R, Alfson KJ, Kalina WV, Kaushal D, Shi PY, Klamp T, Rosenbaum C, Kuhn AN, Tureci O, Dormitzer PR, Jansen KU, Sahin U
Nature (2021) 592 pp. 283-289 [ Pubmed: 33524990 DOI: doi:10.1038/s41586-021-03275-y ]
- Spike glycoprotein, envelope glycoprotein fusion (29 kDa, Protein from Human immunodeficiency virus 1)
- Human ace2 receptor complexed with protein encoded by vaccine candidate bnt162b1 (Complex)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (Complex from Homo sapiens)
- Spike glycoprotein, envelope glycoprotein fusion (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of protein encoded by vaccine candidate BNT162b2
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7l7k
Q-score: 0.484
Vogel AB, Kanevsky I, Che Y, Swanson KA, Muik A, Vormehr M, Kranz LM, Walzer KC, Hein S, Guler A, Loschko J, Maddur MS, Ota-Setlik A, Tompkins K, Cole J, Lui BG, Ziegenhals T, Plaschke A, Eisel D, Dany SC, Fesser S, Erbar S, Bates F, Schneider D, Jesionek B, Sanger B, Wallisch AK, Feuchter Y, Junginger H, Krumm SA, Heinen AP, Adams-Quack P, Schlereth J, Schille S, Kroner C, de la Caridad Guimil Garcia R, Hiller T, Fischer L, Sellers RS, Choudhary S, Gonzalez O, Vascotto F, Gutman MR, Fontenot JA, Hall-Ursone S, Brasky K, Griffor MC, Han S, Su AAH, Lees JA, Nedoma NL, Mashalidis EH, Sahasrabudhe PV, Tan CY, Pavliakova D, Singh G, Fontes-Garfias C, Pride M, Scully IL, Ciolino T, Obregon J, Gazi M, Carrion Jr R, Alfson KJ, Kalina WV, Kaushal D, Shi PY, Klamp T, Rosenbaum C, Kuhn AN, Tureci O, Dormitzer PR, Jansen KU, Sahin U
Nature (2021) 592 pp. 283-289 [ Pubmed: 33524990 DOI: doi:10.1038/s41586-021-03275-y ]