cryo-EM structure of a non-neutralizing antibody V3-21 in complex with SARS-CoV-2 spike
Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, Gonzalez-Dominguez I, Edgar JE, Bournazos S, Sun W, Carreno JM, Simon V, Ellebedy AH, Bajic G, Krammer F
Cell Rep (2024) 43 pp. 114922-114922 [ DOI: doi:10.1016/j.celrep.2024.114922 Pubmed: 39504245 ]
- Fab:spike complex (500 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
cryo-EM structure of a non-neutralizing antibody V6-12 in complex with SARS-CoV-2 spike
Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, Gonzalez-Dominguez I, Edgar JE, Bournazos S, Sun W, Carreno JM, Simon V, Ellebedy AH, Bajic G, Krammer F
Cell Rep (2024) 43 pp. 114922-114922 [ DOI: doi:10.1016/j.celrep.2024.114922 Pubmed: 39504245 ]
- Fab:spike complex (500 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8via
Q-score: 0.302
Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, Gonzalez-Dominguez I, Edgar JE, Bournazos S, Sun W, Carreno JM, Simon V, Ellebedy AH, Bajic G, Krammer F
Cell Rep (2024) 43 pp. 114922-114922 [ DOI: doi:10.1016/j.celrep.2024.114922 Pubmed: 39504245 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (74 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2 (62 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with pvi.v5-4 fab (500 MDa, Complex from Homo sapiens)
- Pvi.v5-4 heavy chain (25 kDa, Protein from Homo sapiens)
- Pvi.v5-4 light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7l7f
Q-score: 0.517
Vogel AB, Kanevsky I, Che Y, Swanson KA, Muik A, Vormehr M, Kranz LM, Walzer KC, Hein S, Guler A, Loschko J, Maddur MS, Ota-Setlik A, Tompkins K, Cole J, Lui BG, Ziegenhals T, Plaschke A, Eisel D, Dany SC, Fesser S, Erbar S, Bates F, Schneider D, Jesionek B, Sanger B, Wallisch AK, Feuchter Y, Junginger H, Krumm SA, Heinen AP, Adams-Quack P, Schlereth J, Schille S, Kroner C, de la Caridad Guimil Garcia R, Hiller T, Fischer L, Sellers RS, Choudhary S, Gonzalez O, Vascotto F, Gutman MR, Fontenot JA, Hall-Ursone S, Brasky K, Griffor MC, Han S, Su AAH, Lees JA, Nedoma NL, Mashalidis EH, Sahasrabudhe PV, Tan CY, Pavliakova D, Singh G, Fontes-Garfias C, Pride M, Scully IL, Ciolino T, Obregon J, Gazi M, Carrion Jr R, Alfson KJ, Kalina WV, Kaushal D, Shi PY, Klamp T, Rosenbaum C, Kuhn AN, Tureci O, Dormitzer PR, Jansen KU, Sahin U
Nature (2021) 592 pp. 283-289 [ Pubmed: 33524990 DOI: doi:10.1038/s41586-021-03275-y ]
- Spike glycoprotein, envelope glycoprotein fusion (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (Complex from Homo sapiens)
- Spike glycoprotein, envelope glycoprotein fusion (29 kDa, Protein from Human immunodeficiency virus 1)
- Human ace2 receptor complexed with protein encoded by vaccine candidate bnt162b1 (Complex)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
Cryo-EM structure of protein encoded by vaccine candidate BNT162b2
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7l7k
Q-score: 0.484
Vogel AB, Kanevsky I, Che Y, Swanson KA, Muik A, Vormehr M, Kranz LM, Walzer KC, Hein S, Guler A, Loschko J, Maddur MS, Ota-Setlik A, Tompkins K, Cole J, Lui BG, Ziegenhals T, Plaschke A, Eisel D, Dany SC, Fesser S, Erbar S, Bates F, Schneider D, Jesionek B, Sanger B, Wallisch AK, Feuchter Y, Junginger H, Krumm SA, Heinen AP, Adams-Quack P, Schlereth J, Schille S, Kroner C, de la Caridad Guimil Garcia R, Hiller T, Fischer L, Sellers RS, Choudhary S, Gonzalez O, Vascotto F, Gutman MR, Fontenot JA, Hall-Ursone S, Brasky K, Griffor MC, Han S, Su AAH, Lees JA, Nedoma NL, Mashalidis EH, Sahasrabudhe PV, Tan CY, Pavliakova D, Singh G, Fontes-Garfias C, Pride M, Scully IL, Ciolino T, Obregon J, Gazi M, Carrion Jr R, Alfson KJ, Kalina WV, Kaushal D, Shi PY, Klamp T, Rosenbaum C, Kuhn AN, Tureci O, Dormitzer PR, Jansen KU, Sahin U
Nature (2021) 592 pp. 283-289 [ Pubmed: 33524990 DOI: doi:10.1038/s41586-021-03275-y ]