Li C, Smirnova E, Schnitzler C, Crucifix C, Concordet JP, Brion A, Poterszman A, Schultz P, Papai G, Ben-Shem A
Nature (2024) 635 pp. 764-769 [ Pubmed: 39260417 DOI: doi:10.1038/s41586-024-08011-w ]
- Ruvbl2 (Protein from Homo sapiens)
- Epc1 (Protein from Homo sapiens)
- Vps72 (Protein from Homo sapiens)
- Dmap1 (Protein from Homo sapiens)
- Acl6a (Protein from Homo sapiens)
- Ruvbl1 (Protein from Homo sapiens)
- Tip60 complex (Cell from Homo sapiens)
- Ep400 (Protein from Homo sapiens)
- Actin (Protein from Homo sapiens)
Human Tip60 complex locally refined on RUVBL1/2
Li C, Smirnova E, Schnitzler C, Crucifix C, Concordet JP, Brion A, Poterszman A, Schultz P, Papai G, Ben-Shem A
Nature (2024) 635 pp. 764-769 [ Pubmed: 39260417 DOI: doi:10.1038/s41586-024-08011-w ]
- Ruvbl2 (Protein from Homo sapiens)
- Epc1 (Protein from Homo sapiens)
- Vps72 (Protein from Homo sapiens)
- Acl6a (Protein from Homo sapiens)
- Dmap1 (Protein from Homo sapiens)
- Ruvbl1 (Protein from Homo sapiens)
- Tip60 complex (Cell from Homo sapiens)
- Ep400 (Protein from Homo sapiens)
- Actin (Protein from Homo sapiens)
Tip60 complex locally refined on ARP domain
Li C, Smirnova E, Schnitzler C, Crucifix C, Concordet JP, Brion A, Poterszman A, Schultz P, Papai G, Ben-Shem A
Nature (2024) 635 pp. 764-769 [ Pubmed: 39260417 DOI: doi:10.1038/s41586-024-08011-w ]
- Ruvbl2 (Protein from Homo sapiens)
- Epc1 (Protein from Homo sapiens)
- Vps72 (Protein from Homo sapiens)
- Dmap1 (Protein from Homo sapiens)
- Acl6a (Protein from Homo sapiens)
- Ruvbl1 (Protein from Homo sapiens)
- Tip60 complex (Cell from Homo sapiens)
- Ep400 (Protein from Homo sapiens)
- Actin (Protein from Homo sapiens)
Cryo-EM structure of the human Tip60 complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8qr1
Q-score: 0.484
Li C, Smirnova E, Schnitzler C, Crucifix C, Concordet JP, Brion A, Poterszman A, Schultz P, Papai G, Ben-Shem A
Nature (2024) 635 pp. 764-769 [ Pubmed: 39260417 DOI: doi:10.1038/s41586-024-08011-w ]
- Ruvb-like 2 (51 kDa, Protein from Homo sapiens)
- Dna methyltransferase 1-associated protein 1 (53 kDa, Protein from Homo sapiens)
- Actin-like protein 6a (47 kDa, Protein from Homo sapiens)
- Ruvb-like 1 (50 kDa, Protein from Homo sapiens)
- E1a-binding protein p400 (343 kDa, Protein from Homo sapiens)
- Enhancer of polycomb homolog 1 (93 kDa, Protein from Homo sapiens)
- Tip60 complex (Cell from Homo sapiens)
- Actin, cytoplasmic 1, n-terminally processed (41 kDa, Protein from Homo sapiens)
- Vacuolar protein sorting-associated protein 72 homolog (40 kDa, Protein from Homo sapiens)
Smirnova E, Bignon E, Schultz P, Papai G, Ben Shem A
eLife (2024) 12 [ DOI: doi:10.7554/eLife.87989 Pubmed: 38415718 ]
- Dna (Complex)
- Dna (145-mer) (DNA from synthetic construct)
- Histone h2b (Protein from Xenopus laevis)
- Human nad-dependent protein deacylase sirtuin-6 (Complex from Homo sapiens)
- Histone h4 (Protein from Xenopus laevis)
- Histones (Complex from Xenopus laevis)
- Human nad-dependent protein deacylase sirtuin-6 (Protein from Homo sapiens)
- Histone h3 (Protein from Xenopus laevis)
- Human sirtuin 6 in complex with the nucleosome (Complex)
- Histone h2a (Protein from Xenopus laevis)
Nucleosome Bound human SIRT6 (composite structure)
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8of4
Q-score: 0.446
Smirnova E, Bignon E, Schultz P, Papai G, Ben Shem A
eLife (2024) 12 [ DOI: doi:10.7554/eLife.87989 Pubmed: 38415718 ]
- Histone h2b (13 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Dna (145-mer) (44 kDa, DNA from Xenopus laevis)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Dna (145-mer) (44 kDa, DNA from Xenopus laevis)
- Nad-dependent protein deacylase sirtuin-6 (39 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Sirt6 (Complex from Homo sapiens)
- Human sirtuin 6 in complex with the nucleosome (Complex from Xenopus laevis)