10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
Negative stain EM map of BG505 SOSIP in complex with Rh4O9.8 monoclonal antibody (as Fab fragment)
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ DOI: doi:10.1126/sciadv.abk2039 Pubmed: 35044813 ]
BG505 SOSIP.v5.2 in complex with the polyclonal Fab pAbC-1 from animal Rh.4O9
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7mdt
Q-score: 0.481
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ Pubmed: 35044813 DOI: doi:10.1126/sciadv.abk2039 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rh4o9.8 monoclonal antibody heavy chain (12 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip.v5.2 in complex with the polyclonal fab sample isolated from animal rh4o9. (Complex from Human immunodeficiency virus)
- Rh4o9.8 monoclonal antibody light chain (11 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 SOSIP MD39 in complex with the monoclonal antibodies Rh.33104 mAb.1 and RM20A3
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7mdu
Q-score: 0.517
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ Pubmed: 35044813 DOI: doi:10.1126/sciadv.abk2039 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip md39 in complex with the monoclonal antibodies rh.33104 mab.1 and rm20a3 (Complex from Macaca mulatta)
- Surface protein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Rh.33104 mab.1 heavy chain (12 kDa, Protein from Macaca mulatta)
- Rh.33104 mab.1 light chain (11 kDa, Protein from Macaca mulatta)
- Rm20a3 mab heavy chain (13 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 mab light chain (11 kDa, Protein from Macaca mulatta)
BG505 SOSIP.v5.2(7S) in complex with the monoclonal antibodies Rh.33172 mAb.1 and RM19R
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7mep
Q-score: 0.486
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ DOI: doi:10.1126/sciadv.abk2039 Pubmed: 35044813 ]
- Rm19r mab light chain (11 kDa, Protein from Macaca mulatta)
- Bg505 sosipv5.2(7s) - gp120 (74 kDa, Protein from Human immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm19r mab heavy chain (13 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2(7s) in complex with the monoclonal antibodies rh.33172 mab.1 and rm19r (Complex)
- Monoclonal antibodies rh.33172 mab.1 and rm19r (Complex from Macaca mulatta)
- Rh.33172 mab.1 heavy chain (14 kDa, Protein from Macaca mulatta)
- Rh.33172 mab.1 light chain (11 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2(7s) (Complex from Human immunodeficiency virus)
RM19M Fab in complex with BG505 SOSIPv5.2
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ DOI: doi:10.1371/journal.ppat.1008753 Pubmed: 32866207 ]
RM19A1 Fab in complex with BG505 SOSIPv5.2
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ DOI: doi:10.1371/journal.ppat.1008753 Pubmed: 32866207 ]
RM19P Fab in complex with BG505 SOSIPv5.2
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ DOI: doi:10.1371/journal.ppat.1008753 Pubmed: 32866207 ]
RM19O Fab in complex with BG505 SOSIPv5.2
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ DOI: doi:10.1371/journal.ppat.1008753 Pubmed: 32866207 ]
RM19L Fab in complex with BG505 SOSIPv5.2
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ DOI: doi:10.1371/journal.ppat.1008753 Pubmed: 32866207 ]