10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8f9g
Q-score: 0.446
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ DOI: doi:10.1126/science.adk0582 Pubmed: 38753770 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
- V3-glycan epitope polyclonal fab heavy chain (10 kDa, Protein from Mus musculus)
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized bg18hcgl knock-in mice v3-glycan epitope polyclonal fab heavy chain (Complex from Mus musculus)
- V3-glycan epitope polyclonal fab light chain (8 kDa, Protein from Mus musculus)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8f9m
Q-score: 0.346
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ Pubmed: 38753770 DOI: doi:10.1126/science.adk0582 ]
- V3-glycan epitope polyclonal fab heavy chain (9 kDa, Protein from Mus musculus)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- V3-glycan epitope polyclonal fab light chain (9 kDa, Protein from Mus musculus)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized wild type mice, and nhp monoclonal fab rm20a3 (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8dt8
Q-score: 0.443
Misson Mindrebo L, Liu H, Ozorowski G, Tran Q, Woehl J, Khalek I, Smith JM, Barman S, Zhao F, Keating C, Limbo O, Verma M, Liu J, Stanfield RL, Zhu X, Turner HL, Sok D, Huang PS, Burton DR, Ward AB, Wilson IA, Jardine JG
PNAS (2023) 120 pp. e2216612120-e2216612120 [ Pubmed: 37276407 DOI: doi:10.1073/pnas.2216612120 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lm18/nb136 bispecific tetra-nanobody immunoglobulin in complex with sars-cov-2-6p-mut7 s protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Lm18 nanobody (14 kDa, Protein from synthetic construct)
- Nb136 nanobody (13 kDa, Protein from synthetic construct)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)