Heterodimeric ABC exporter TmrAB in inward-facing narrow conformation under turnover conditions
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6raf
Q-score: 0.407
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Bruchert S, Kuhn BT, Geertsma ER, Hummer G, Tampe R, Moeller A
Nature (2019) 571 pp. 580-583 [ Pubmed: 31316210 DOI: doi:10.1038/s41586-019-1391-0 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Anti-vesicular stomatitis virus n vhh (Complex from Vicugna pacos)
- Tmrab in inward-facing narrow conformation (150 kDa, Complex)
- Anti-vesicular stomatitis virus n vhh (14 kDa, Protein from Vicugna pacos)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Multidrug resistance abc transporter atp-binding and permease protein (Complex from Thermus thermophilus HB27)
- Magnesium ion (24 Da, Ligand)
- Multidrug resistance abc transporter atp-binding and permease protein (Complex from Thermus thermophilus)
- Multidrug resistance abc transporter atp-binding and permease protein (70 kDa, Protein from Thermus thermophilus HB27)
- Multidrug resistance abc transporter atp-binding and permease protein (64 kDa, Protein from Thermus thermophilus)
Heterodimeric ABC exporter TmrAB in inward-facing wide conformation under turnover conditions
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6rag
Q-score: 0.356
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Bruchert S, Kuhn BT, Geertsma ER, Hummer G, Tampe R, Moeller A
Nature (2019) 571 pp. 580-583 [ Pubmed: 31316210 DOI: doi:10.1038/s41586-019-1391-0 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Tmrab in inward-facing wide conformation (150 kDa, Complex)
- Tmrab (Complex from Thermus thermophilus)
- Multidrug resistance abc transporter atp-binding and permease protein (70 kDa, Protein from Thermus thermophilus)
- Nanobody (Complex from Vicugna pacos)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Nanobody nb9f10 (14 kDa, Protein from Vicugna pacos)
- Multidrug resistance abc transporter atp-binding and permease protein (64 kDa, Protein from Thermus thermophilus)
Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing open conformation
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6rah
Q-score: 0.534
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Bruchert S, Kuhn BT, Geertsma ER, Hummer G, Tampe R, Moeller A
Nature (2019) 571 pp. 580-583 [ Pubmed: 31316210 DOI: doi:10.1038/s41586-019-1391-0 ]
- Tmrab eq mutant in atp bound outward-facing open conformation (Complex from Vicugna pacos)
- Tmrab eq mutant in atp bound outward-facing open conformation (Complex from Thermus thermophilus)
- Multidrug resistance abc transporter atp-binding and permease protein (70 kDa, Protein from Thermus thermophilus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Tmrab eq mutant in atp bound outward-facing open conformation (150 kDa, Complex)
- Nanobody nb9f10 (14 kDa, Protein from Vicugna pacos)
- Water (18 Da, Ligand)
- Multidrug resistance abc transporter atp-binding and permease protein (64 kDa, Protein from Thermus thermophilus)
Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing occluded conformation
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6rai
Q-score: 0.539
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Bruchert S, Kuhn BT, Geertsma ER, Hummer G, Tampe R, Moeller A
Nature (2019) 571 pp. 580-583 [ Pubmed: 31316210 DOI: doi:10.1038/s41586-019-1391-0 ]
- Tmrab (Complex from Thermus thermophilus)
- Tmrab eq mutant in atp bound outward-occluded conformation (150 kDa, Complex)
- Nanobody (Complex from Vicugna pacos)
- Multidrug resistance abc transporter atp-binding and permease protein (70 kDa, Protein from Thermus thermophilus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Nanobody nb9f10 (14 kDa, Protein from Vicugna pacos)
- Water (18 Da, Ligand)
- Multidrug resistance abc transporter atp-binding and permease protein (64 kDa, Protein from Thermus thermophilus)
Heterodimeric ABC exporter TmrAB in vanadate trapped outward-facing open conformation
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6raj
Q-score: 0.481
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Bruchert S, Kuhn BT, Geertsma ER, Hummer G, Tampe R, Moeller A
Nature (2019) 571 pp. 580-583 [ Pubmed: 31316210 DOI: doi:10.1038/s41586-019-1391-0 ]
- Tmrab in vanadate trapped outward facing open conformation (150 kDa, Complex)
- Adp orthovanadate (544 Da, Ligand)
- Nanobody nb9f10 (Complex from Vicugna pacos)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Multidrug resistance abc transporter atp-binding and permease protein (Complex from Thermus thermophilus HB27)
- Magnesium ion (24 Da, Ligand)
- Multidrug resistance abc transporter atp-binding and permease protein (Complex from Thermus thermophilus)
- Nanobody nb9f10 (14 kDa, Protein from Vicugna pacos)
- Multidrug resistance abc transporter atp-binding and permease protein (70 kDa, Protein from Thermus thermophilus HB27)
- Multidrug resistance abc transporter atp-binding and permease protein (64 kDa, Protein from Thermus thermophilus)
Heterodimeric ABC exporter TmrAB in vanadate trapped outward-facing occluded conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6rak
Q-score: 0.531
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Bruchert S, Kuhn BT, Geertsma ER, Hummer G, Tampe R, Moeller A
Nature (2019) 571 pp. 580-583 [ Pubmed: 31316210 DOI: doi:10.1038/s41586-019-1391-0 ]
- Adp orthovanadate (544 Da, Ligand)
- Multidrug resistance abc transporter atp-binding and permease protein (70 kDa, Protein from Thermus thermophilus)
- Tmrab in vanadate trapped of occluded conformation (Complex from Thermus thermophilus)
- Tmrab in vanadate trapped of occluded conformation (Complex from Vicugna pacos)
- Tmrab in vanadate trapped of occluded conformation (150 kDa, Complex)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Nanobody nb9f10 (14 kDa, Protein from Vicugna pacos)
- Multidrug resistance abc transporter atp-binding and permease protein (64 kDa, Protein from Thermus thermophilus)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6ral
Q-score: 0.488
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Bruchert S, Kuhn BT, Geertsma ER, Hummer G, Tampe R, Moeller A
Nature (2019) 571 pp. 580-583 [ Pubmed: 31316210 DOI: doi:10.1038/s41586-019-1391-0 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Tmrab in asymmetric unlocked return conformation under turnover conditions (150 kDa, Complex)
- Multidrug resistance abc transporter atp-binding and permease protein (70 kDa, Protein from Thermus thermophilus)
- Nanobody nb9f10 (Complex from Vicugna pacos)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Multidrug resistance abc transporter atp-binding and permease protein (Complex from Thermus thermophilus)
- Nanobody nb9f10 (14 kDa, Protein from Vicugna pacos)
- Multidrug resistance abc transporter atp-binding and permease protein (64 kDa, Protein from Thermus thermophilus)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6ram
Q-score: 0.378
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Bruchert S, Kuhn BT, Geertsma ER, Hummer G, Tampe R, Moeller A
Nature (2019) 571 pp. 580-583 [ Pubmed: 31316210 DOI: doi:10.1038/s41586-019-1391-0 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Tmrab (Complex from Thermus thermophilus)
- Multidrug resistance abc transporter atp-binding and permease protein (70 kDa, Protein from Thermus thermophilus)
- Nanobody (Complex from Vicugna pacos)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Nanobody nb9f10 (14 kDa, Protein from Vicugna pacos)
- Tmrab under turnover conditions in asymmetric unlocked return conformation with wider opened intracellular gate (150 kDa, Complex)
- Multidrug resistance abc transporter atp-binding and permease protein (64 kDa, Protein from Thermus thermophilus)
Heterodimeric ABC exporter TmrAB with bound peptide substrate in inward-facing wide conformation
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6ran
Q-score: 0.306
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Bruchert S, Kuhn BT, Geertsma ER, Hummer G, Tampe R, Moeller A
Nature (2019) 571 pp. 580-583 [ Pubmed: 31316210 DOI: doi:10.1038/s41586-019-1391-0 ]
- Tmrab eq mutant with bound peptide-substrate in if wide conformation (Complex from Thermus thermophilus)
- Tmrab eq mutant with bound peptide-substrate in if wide conformation (Complex from Vicugna pacos)
- Multidrug resistance abc transporter atp-binding and permease protein (70 kDa, Protein from Thermus thermophilus)
- Nanobody nb9f10 (14 kDa, Protein from Vicugna pacos)
- Tmrab eq mutant with bound peptide-substrate in if wide conformation (150 kDa, Complex)
- Multidrug resistance abc transporter atp-binding and permease protein (64 kDa, Protein from Thermus thermophilus)