Human tRNA Splicing Endonuclease Complex bound to 2'F-tRNA-Arg
Hayne CK, Butay KJU, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch RM, Deterding LJ, Matera AG, Borgnia MJ, Stanley RE
Nat Struct Mol Biol (2023) 30 pp. 824-833 [ Pubmed: 37231153 DOI: doi:10.1038/s41594-023-00991-z ]
Human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7uxa
Q-score: 0.472
Hayne CK, Butay KJU, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch RM, Deterding LJ, Matera AG, Borgnia MJ, Stanley RE
Nat Struct Mol Biol (2023) 30 pp. 824-833 [ Pubmed: 37231153 DOI: doi:10.1038/s41594-023-00991-z ]
- Rna (78-mer) (28 kDa, RNA from synthetic construct)
- Trna-splicing endonuclease subunit sen15 (19 kDa, Protein from Homo sapiens)
- Human trna splicing endonuclease complex bound to pre-trna-arg (203 kDa, Complex from Homo sapiens)
- Trna-splicing endonuclease subunit sen34 (37 kDa, Protein from Homo sapiens)
- Trna-splicing endonuclease subunit sen2 (55 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Trna-splicing endonuclease subunit sen54 (61 kDa, Protein from Homo sapiens)
SARS-CoV-2 Nsp15 endoribonuclease pre-cleavage state
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7n33
Q-score: 0.606
Frazier MN, Dillard LB, Krahn JM, Perera L, Williams JG, Wilson IM, Stewart ZD, Pillon MC, Deterding LJ, Borgnia MJ, Stanley RE
Nucleic Acids Res (2021) 49 pp. 10136-10149 [ Pubmed: 34403466 DOI: doi:10.1093/nar/gkab719 ]
SARS-CoV-2 Nsp15 endoribonuclease post-cleavage state
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7n06
Q-score: 0.703
Frazier MN, Dillard LB, Krahn JM, Perera L, Williams JG, Wilson IM, Stewart ZD, Pillon MC, Deterding LJ, Borgnia MJ, Stanley RE
Nucleic Acids Res (2021) 49 pp. 10136-10149 [ Pubmed: 34403466 DOI: doi:10.1093/nar/gkab719 ]
- Rna (5'-r(*ap*up*a)-3') (919 Da, RNA from Homo sapiens)
- Uridylate-specific endoribonuclease (42 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Water (18 Da, Ligand)
- Nsp15 viral endoribonuclease in a post-cleavage state (250 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
Nucleotide bound SARS-CoV-2 Nsp15
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7k0r
Q-score: 0.431
Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE
Nat Commun (2021) 12 pp. 636-636 [ Pubmed: 33504779 DOI: doi:10.1038/s41467-020-20608-z ]
- Uridine-5'-monophosphate (324 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Nucleotide bound complex of sars-cov-2 nsp15 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Uridylate-specific endoribonuclease (40 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE
Nat Commun (2021) 12 pp. 636-636 [ Pubmed: 33504779 DOI: doi:10.1038/s41467-020-20608-z ]
SARS-CoV-2 Nsp15 H235A variant APO-state, dataset ii
Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE
Nat Commun (2021) 12 pp. 636-636 [ Pubmed: 33504779 DOI: doi:10.1038/s41467-020-20608-z ]
SARS-CoV-2 Nsp15 H235A APO-state, dataset i
Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE
Nat Commun (2021) 12 pp. 636-636 [ Pubmed: 33504779 DOI: doi:10.1038/s41467-020-20608-z ]