Apo form metabotropic glutamate receptor 5 with Nanobody 43
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK
Nature (2019) 566 pp. 79-84 [ DOI: doi:10.1038/s41586-019-0881-4 Pubmed: 30675062 ]
- Nanobody 43 (Protein from Lama glama)
- Metabotropic glutamate receptor 5 - nb43 complex (220 kDa, Complex from Homo sapiens)
- Metabotropic glutamate receptor 5 (Protein from Homo sapiens)
Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6n51
Q-score: 0.341
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK
Nature (2019) 566 pp. 79-84 [ DOI: doi:10.1038/s41586-019-0881-4 Pubmed: 30675062 ]
- Nanobody 43 (13 kDa, Protein from Lama glama)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 5 (90 kDa, Protein from Homo sapiens)
- Complex between metabotropic glutamate receptor 5 bound to l-quisqualate and nb43 (220 kDa, Complex from Homo sapiens)
- (s)-2-amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid (189 Da, Ligand)
Metabotropic Glutamate Receptor 5 Apo Form
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6n52
Q-score: 0.312
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK
Nature (2019) 566 pp. 79-84 [ DOI: doi:10.1038/s41586-019-0881-4 Pubmed: 30675062 ]
- Metabotropic glutamate receptor 5 (97 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 5 in nanodiscs (200 kDa, Complex from Homo sapiens)
Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 5vai
Q-score: 0.297
Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G
Nature (2017) 546 pp. 248-253 [ DOI: doi:10.1038/nature22394 Pubmed: 28538729 ]
- The activated glucagon-like peptide-1 receptor in complex with the heterotrimeric gs protein (150 kDa, Complex from Oryctolagus cuniculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Uncharacterized protein (52 kDa, Protein from Oryctolagus cuniculus)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Glucagon-like peptide 1 (3 kDa, Protein from Homo sapiens)