CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8jgb
Q-score: 0.551
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Mas-related g-protein coupled receptor member x1 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the bam8-22-bound mrgprx1-gq complex (Complex from Homo sapiens)
- Conorfamide-tx2 (2 kDa, Protein from Conus textile)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8jgf
Q-score: 0.486
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Bam8-22 (1 kDa, Protein from Homo sapiens)
- Cryo-em structure of the bam8-22-bound mrgprx1-gq complex (Complex from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein gq (41 kDa, Protein from Homo sapiens)
- Single-chain fragment variable 16 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jgg
Q-score: 0.54
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Bam8-22 (1 kDa, Protein from Homo sapiens)
- Single-chain fragment variable 16 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cryoem structure of gi-coupled mrgprx1 with peptide agonist bam8-22 (Complex from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7vdh
Q-score: 0.53
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Cholesterol (386 Da, Ligand)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with c48/80, state2 (Complex from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{n}-methyl-ethanamine (519 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7vdl
Q-score: 0.5
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Cholesterol (386 Da, Ligand)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- The pseudoallergen receptor mrgprx2 complex with circular cortistatin-14 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Circular cortistatin-14 (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7vdm
Q-score: 0.531
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Peptide from protachykinin-1 (1 kDa, Protein from Homo sapiens)
- The pseudoallergen receptor mrgprx2 complex with substance p (Complex from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12. state1
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 7vuy
Q-score: 0.509
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, state1 (Complex from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7vuz
Q-score: 0.459
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, state2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv (30 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, local
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7vv0
Q-score: 0.469
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, local (Complex from Homo sapiens)
- Peptide from pro-adrenomedullin (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7vv3
Q-score: 0.531
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with linear cortistatin-14 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv (30 kDa, Protein from Homo sapiens)