Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7xxh
Q-score: 0.443
Li B, Han S, Wang M, Yu Y, Ma L, Chu X, Tan Q, Zhao Q, Wu B
Protein Cell (2023) 14 pp. 382-386 [ Pubmed: 37155313 DOI: doi:10.1093/procel/pwac025 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- P2y purinoceptor 1 (46 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate) (473 Da, Ligand)
- Guanine nucleotide-binding protein g(11) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- The purinergic receptor p2y1r in complex with 2mesadp, g11 and scfv16 (10 MDa, Complex from Homo sapiens)
Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7xxi
Q-score: 0.445
Li B, Han S, Wang M, Yu Y, Ma L, Chu X, Tan Q, Zhao Q, Wu B
Protein Cell (2023) 14 pp. 382-386 [ Pubmed: 37155313 DOI: doi:10.1093/procel/pwac025 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate) (473 Da, Ligand)
- P2y purinoceptor 12 (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- The purinergic receptor p2y12r in complex with 2mesadp and gi (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human glucagon receptor in complex with Gs
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6lmk
Q-score: 0.443
Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B
Science (2020) 367 pp. 1346-1352 [ DOI: doi:10.1126/science.aaz5346 Pubmed: 32193322 ]
- Nb35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glucagon (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Glucagon receptor (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Complex of glucagon receptor bound to glucagon, gs protein and nanobody (Complex from Homo sapiens)
Cryo-EM structure of the human glucagon receptor in complex with Gi1
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6lml
Q-score: 0.425
Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B
Science (2020) 367 pp. 1346-1352 [ DOI: doi:10.1126/science.aaz5346 Pubmed: 32193322 ]
- Glucagon receptor (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Glucagon (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Complex of glucagon receptor bound to glucagon, gi1 protein and antibody (Complex from Homo sapiens)