CryoEM Structure of a FtsH Helical Assembly in the Presence of ATP
Resolution: 2.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 8vw9
Q-score: 0.659
Li Y, Zhu J, Zhang Z, Wei J, Wang F, Meisl G, Knowles TPJ, Egelman EH, Tezcan FA
Nat Chem Biol (2025) [ Pubmed: 39806067 DOI: doi:10.1038/s41589-024-01811-1 ]
- Cryo-em structure of ftsh helical assembly (Complex from Thermotoga maritima)
- Atp-dependent zinc metalloprotease ftsh (51 kDa, Protein from Thermotoga maritima)
- Zinc ion (65 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
CryoEM Structure of a FtsH Helical Assembly in the Presence of ATP
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8vwa
Q-score: 0.665
Li Y, Zhu J, Zhang Z, Wei J, Wang F, Meisl G, Knowles TPJ, Egelman EH, Tezcan FA
Nat Chem Biol (2025) [ DOI: doi:10.1038/s41589-024-01811-1 Pubmed: 39806067 ]
- Atp-dependent zinc metalloprotease ftsh (51 kDa, Protein from Thermotoga maritima)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cryoem structure of ftsh helical assembly (Complex from Thermotoga maritima)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
CryoEM Structure of a FtsH Helical Assembly in the Aged State
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8vwb
Q-score: 0.649
Li Y, Zhu J, Zhang Z, Wei J, Wang F, Meisl G, Knowles TPJ, Egelman EH, Tezcan FA
Nat Chem Biol (2025) [ Pubmed: 39806067 DOI: doi:10.1038/s41589-024-01811-1 ]
- Atp-dependent zinc metalloprotease ftsh (51 kDa, Protein from Thermotoga maritima)
- Cryoem structure of a ftsh helical assembly in the aged state (Complex from Thermotoga maritima)
- Zinc ion (65 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
CryoEM Structure of a FtsH Helical Assembly in the Aged State
Resolution: 2.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 8vwc
Q-score: 0.664
Li Y, Zhu J, Zhang Z, Wei J, Wang F, Meisl G, Knowles TPJ, Egelman EH, Tezcan FA
Nat Chem Biol (2025) [ DOI: doi:10.1038/s41589-024-01811-1 Pubmed: 39806067 ]
- Atp-dependent zinc metalloprotease ftsh (51 kDa, Protein from Thermotoga maritima)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cryo-em structure of ftsh helical assembly in the aged state (Complex from Thermotoga maritima)
- Zinc ion (65 Da, Ligand)
Azotobacter vinelandii MoFeP (C2 symmetry)
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 9ctz
Q-score: 0.621
Narehood SM, Cook BD, Srisantitham S, Eng VH, Shiau AA, McGuire KL, Britt RD, Herzik Jr MA, Tezcan FA
Nature (2025) 637 pp. 991-997 [ Pubmed: 39779844 DOI: doi:10.1038/s41586-024-08311-1 ]
- Water (18 Da, Ligand)
- Nitrogenase molybdenum-iron protein alpha chain (55 kDa, Protein from Azotobacter vinelandii)
- 3-hydroxy-3-carboxy-adipic acid (206 Da, Ligand)
- Nitrogenase molybdenum-iron protein beta chain (59 kDa, Protein from Azotobacter vinelandii)
- Iron-sulfur-molybdenum cluster with interstitial carbon (787 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Azotobacter vinelandii mofep (c2 symmetry) (230 kDa, Complex from Azotobacter vinelandii)
- Fe(8)-s(7) cluster (671 Da, Ligand)
Azotobacter vinelandii 1:1:1 MoFeP:FeP:FeSII-Complex (C1 symmetry)
Resolution: 3.94 Å
EM Method: Single-particle
Fitted PDBs: 9cu0
Q-score: 0.372
Narehood SM, Cook BD, Srisantitham S, Eng VH, Shiau AA, McGuire KL, Britt RD, Herzik Jr MA, Tezcan FA
Nature (2025) 637 pp. 991-997 [ DOI: doi:10.1038/s41586-024-08311-1 Pubmed: 39779844 ]
- Fe(8)-s(7) cluster (671 Da, Ligand)
- Water (18 Da, Ligand)
- Protein fesii (13 kDa, Protein from Azotobacter vinelandii)
- Nitrogenase molybdenum-iron protein beta chain (59 kDa, Protein from Azotobacter vinelandii)
- Nitrogenase molybdenum-iron protein alpha chain (55 kDa, Protein from Azotobacter vinelandii)
- Nitrogenase iron protein 1 (31 kDa, Protein from Azotobacter vinelandii)
- Iron/sulfur cluster (351 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Iron-sulfur-molybdenum cluster with interstitial carbon (787 Da, Ligand)
- 3-hydroxy-3-carboxy-adipic acid (206 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Azotobacter vinelandii 1:1:1 mofep:fep:fesii-complex (c1 symmetry) (313 kDa, Complex from Azotobacter vinelandii)
Azotobacter vinelandii filamentous 2:2:1 MoFeP:FeP:FeSII-Complex (termini; C1 symmetry)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 9cu1
Q-score: 0.333
Narehood SM, Cook BD, Srisantitham S, Eng VH, Shiau AA, McGuire KL, Britt RD, Herzik Jr MA, Tezcan FA
Nature (2025) 637 pp. 991-997 [ Pubmed: 39779844 DOI: doi:10.1038/s41586-024-08311-1 ]
- Fe (iii) ion (55 Da, Ligand)
- Azotobacter vinelandii filamentous 2:2:1 mofep:fep:fesii-complex (termini; c1 symmetry) (626 kDa, Complex from Azotobacter vinelandii)
- Fe(8)-s(7) cluster (671 Da, Ligand)
- Water (18 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- Nitrogenase molybdenum-iron protein beta chain (59 kDa, Protein from Azotobacter vinelandii)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nitrogenase molybdenum-iron protein alpha chain (55 kDa, Protein from Azotobacter vinelandii)
- Magnesium ion (24 Da, Ligand)
- Nitrogenase iron protein 1 (31 kDa, Protein from Azotobacter vinelandii)
- Protein fesii (13 kDa, Protein from Azotobacter vinelandii)
- 3-hydroxy-3-carboxy-adipic acid (206 Da, Ligand)
- Protein fesii (13 kDa, Protein from Azotobacter vinelandii)
- Iron-sulfur-molybdenum cluster with interstitial carbon (787 Da, Ligand)
Azotobacter vinelandii filamentous 2:2:1 MoFeP:FeP:FeSII-Complex (C2 symmetry)
Resolution: 2.27 Å
EM Method: Single-particle
Fitted PDBs: 9cu2
Q-score: 0.64
Narehood SM, Cook BD, Srisantitham S, Eng VH, Shiau AA, McGuire KL, Britt RD, Herzik Jr MA, Tezcan FA
Nature (2025) 637 pp. 991-997 [ Pubmed: 39779844 DOI: doi:10.1038/s41586-024-08311-1 ]
- Fe (iii) ion (55 Da, Ligand)
- Fe(8)-s(7) cluster (671 Da, Ligand)
- Water (18 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- Nitrogenase molybdenum-iron protein beta chain (59 kDa, Protein from Azotobacter vinelandii)
- Azotobacter vinelandii filamentous 2:2:1 mofep:fep:fesii-complex (c2 symmetry) (626 kDa, Complex from Azotobacter vinelandii)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nitrogenase molybdenum-iron protein alpha chain (55 kDa, Protein from Azotobacter vinelandii)
- Magnesium ion (24 Da, Ligand)
- Nitrogenase iron protein 1 (31 kDa, Protein from Azotobacter vinelandii)
- Protein fesii (13 kDa, Protein from Azotobacter vinelandii)
- 3-hydroxy-3-carboxy-adipic acid (206 Da, Ligand)
- Protein fesii (13 kDa, Protein from Azotobacter vinelandii)
- Iron-sulfur-molybdenum cluster with interstitial carbon (787 Da, Ligand)
Rutledge HL, Cook BD, Nguyen HPM, Herzik MA, Tezcan FA
Science (2022) 377 pp. 865-869 [ DOI: 10.1126/science.abq7641 Pubmed: 35901182 ]
Image sets:
- Gain file for motion correction of unaligned micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions
- Aligned micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions
- Unaligned micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions
Rutledge HL, Cook BD, Nguyen HPM, Herzik Jr MA, Tezcan FA
Science (2022) 377 pp. 865-869 [ DOI: 10.1126/science.abq7641 Pubmed: 35901182 ]
Image sets:
- Unaligned multi-frame micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions with inhibitor BeFx
- Aligned micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions with inhibitor BeFx.
- Unaligned multi-frame micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions with inhibitor BeFx at 15 degree tilt
- Unaligned multi-frame micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions with inhibitor BeFx at 25 degree tilt
- Aligned micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions with inhibitor BeFx at 25 degree tilt
- Unaligned multi-frame micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions with inhibitor BeFx.
- Aligned micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions with inhibitor BeFx at 15 degree tilt
- Aligned micrographs of nitrogenase (MoFeP + FeP) from Azotobacter vinelandii under catalytic turnover conditions with inhibitor BeFx