Cryo-EM structure of the BRISC complex bound to SHMT2
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6h3c
Q-score: 0.278
Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andres-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guerillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thoma NH
Mol Cell (2019) 75 pp. 483-497.e9 [ DOI: doi:10.1016/j.molcel.2019.06.002 Pubmed: 31253574 ]
- Shmt2 alpha (Complex from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (38 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Brisc complex subunit abraxas 2 (49 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 2 (45 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 1 (39 kDa, Protein from Homo sapiens)
- Brisc complex bound to shmt2 alpha (438 kDa, Complex)
- Serine hydroxymethyltransferase, mitochondrial (56 kDa, Protein from Homo sapiens)
- Brisc complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM structure of CSN-N8-CRL4A at 6.7 A resolution
Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith REJ, Tichkule R, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thoma NH
Nature (2016) 531 pp. 598-603 [ DOI: doi:10.1038/nature17416 Pubmed: 27029275 ]
- Cop9 signalosome subunit 6 (35 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 1 (52 kDa, Protein from Homo sapiens)
- Cul4a (79 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 5 (35 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 2 (49 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 3 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 7a (30 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 4 (44 kDa, Protein from Homo sapiens)
- Recombinant human csn-n8-crl4a complex (493 kDa, Sample)
- Dna damage-binding protein 1 (125 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
Rigid part of the CSN-N8-CRL4A cryo-EM structure at 6.4 A resolution
Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith REJ, Tichkule R, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thoma NH
Nature (2016) 531 pp. 598-603 [ DOI: doi:10.1038/nature17416 Pubmed: 27029275 ]
- Cop9 signalosome subunit 6 (35 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 1 (52 kDa, Protein from Homo sapiens)
- Cul4a (79 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 5 (35 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 2 (49 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 3 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 7a (30 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 4 (44 kDa, Protein from Homo sapiens)
- Recombinant human csn-n8-crl4a complex (493 kDa, Sample)
- Dna damage-binding protein 1 (125 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
Cryo-EM structure of CSN-N8-CRL4A at 8.8 A resolution
Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith REJ, Tichkule R, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thoma NH
Nature (2016) 531 pp. 598-603 [ DOI: doi:10.1038/nature17416 Pubmed: 27029275 ]
- Cop9 signalosome subunit 6 (35 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 1 (52 kDa, Protein from Homo sapiens)
- Cul4a (79 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 5 (35 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 2 (49 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 3 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 7a (30 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 4 (44 kDa, Protein from Homo sapiens)
- Recombinant human csn-n8-crl4a complex (493 kDa, Sample)
- Dna damage-binding protein 1 (125 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
Cryo-EM structure of CSN-N8-CRL4ADDB2 at 8.3 A resolution
Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith REJ, Tichkule R, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thoma NH
Nature (2016) 531 pp. 598-603 [ DOI: doi:10.1038/nature17416 Pubmed: 27029275 ]
- Cop9 signalosome subunit 6 (35 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 1 (52 kDa, Protein from Homo sapiens)
- Cul4a (79 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 2 (39 kDa, Protein from Danio rerio)
- Cop9 signalosome subunit 5 (35 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 2 (49 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 3 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 7a (30 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 4 (44 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (125 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Recombinant human csn-n8-crl4addb2 complex. (533 kDa, Sample)
Negative stain EM structure of CSN-N8-CRL3 at 27 A resolution
Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith REJ, Tichkule R, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thoma NH
Nature (2016) 531 pp. 598-603 [ DOI: doi:10.1038/nature17416 Pubmed: 27029275 ]
- Cop9 signalosome subunit 6 (35 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 1 (52 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 5 (35 kDa, Protein from Homo sapiens)
- Speckle-type poz protein (17 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 2 (49 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 3 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 7a (30 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome subunit 4 (44 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Cul3 (88 kDa, Protein from Homo sapiens)
- Recombinant human csn-n8-crl3 complex (887 kDa, Sample)