Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8r6u
Q-score: 0.565
Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2024) 52 pp. 6049-6065 [ Pubmed: 38709882 DOI: doi:10.1093/nar/gkae330 ]
- Sftsv l protein in complex with 5' and 3' rna, as well as rna acting as a primer. (240 kDa, Complex from SFTS virus AH12)
- Rna-directed rna polymerase l (235 kDa, Protein from SFTS virus AH12)
- Rna primer tail-end (5 kDa, RNA from SFTS virus AH12)
- Magnesium ion (24 Da, Ligand)
- Rna primer (6 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*cp*up*up*up*gp*up*gp*u)-3') (8 kDa, RNA from SFTS virus AH12)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8r6w
Q-score: 0.44
Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2024) 52 pp. 6049-6065 [ Pubmed: 38709882 DOI: doi:10.1093/nar/gkae330 ]
- Sftsv l protein in complex with 5' and 3' rna, as well as rna acting as a primer. (240 kDa, Complex from SFTS virus AH12)
- Rna-directed rna polymerase l (235 kDa, Protein from SFTS virus AH12)
- Rna (5'-r(*(m7g)*ap*ap*a)-3') (5 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(*ap*cp*ap*c)-3') (5 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*cp*up*up*up*gp*up*gp*u)-3') (8 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*cp*ap*g)-3') (6 kDa, RNA from SFTS virus AH12)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8r6y
Q-score: 0.456
Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2024) 52 pp. 6049-6065 [ Pubmed: 38709882 DOI: doi:10.1093/nar/gkae330 ]
- Sftsv l protein in complex with 5' and 3' rna, as well as rna acting as a primer. (240 kDa, Complex from SFTS virus AH12)
- Rna-directed rna polymerase l (235 kDa, Protein from SFTS virus AH12)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*ap*ap*ap*up*gp*u)-3') (6 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(p*ap*cp*a)-3') (918 Da, RNA from SFTS virus AH12)
- Magnesium ion (24 Da, Ligand)
- 5'-o-[(s)-hydroxy{[(s)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine (483 Da, Ligand)
- Rna (5'-r(*(m7g)*ap*ap*a)-3') (5 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*cp*ap*g)-3') (6 kDa, RNA from SFTS virus AH12)
Subtomogram average of Vaccinia A10 trimer with open center from in vitro cores
Liu J, Corroyer-Dulmont S, Prazak V, Khusainov I, Bahrami K, Welsch S, Vasishtan D, Obarska-Kosinska A, Thorkelsson SR, Grunewald K, Quemin ERJ, Turonova B, Locker JK
Nat Struct Mol Biol (2024) 31 pp. 1105-1113 [ DOI: doi:10.1038/s41594-024-01218-5 Pubmed: 38316878 ]
Subtomogram average of Vaccinia A10 trimer with tight center from in vitro cores
Liu J, Corroyer-Dulmont S, Prazak V, Khusainov I, Bahrami K, Welsch S, Vasishtan D, Obarska-Kosinska A, Thorkelsson SR, Grunewald K, Quemin ERJ, Turonova B, Locker JK
Nat Struct Mol Biol (2024) 31 pp. 1105-1113 [ DOI: doi:10.1038/s41594-024-01218-5 Pubmed: 38316878 ]
Subtomogram average of Vaccinia A10 trimer from in situ cores
Liu J, Corroyer-Dulmont S, Prazak V, Khusainov I, Bahrami K, Welsch S, Vasishtan D, Obarska-Kosinska A, Thorkelsson SR, Grunewald K, Quemin ERJ, Turonova B, Locker JK
Nat Struct Mol Biol (2024) 31 pp. 1105-1113 [ DOI: doi:10.1038/s41594-024-01218-5 Pubmed: 38316878 ]
Structure of the SNV L protein bound to 5' RNA
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ci5
Q-score: 0.572
Meier K, Thorkelsson SR, Durieux Trouilleton Q, Vogel D, Yu D, Kosinski J, Cusack S, Malet H, Grunewald K, Quemin ERJ, Rosenthal M
PLoS Pathog (2023) 19 pp. e1011533-e1011533 [ Pubmed: 37549153 DOI: doi:10.1371/journal.ppat.1011533 ]
Structure of the SFTSV L protein bound to 5' cRNA hook [5' HOOK]
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8as6
Q-score: 0.501
Williams HM, Thorkelsson SR, Vogel D, Milewski M, Busch C, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2023) 51 pp. 1424-1442 [ Pubmed: 36651274 DOI: doi:10.1093/nar/gkac1249 ]
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*c)-3') (6 kDa, RNA from SFTS virus AH12)
- Sftsv l protein in complex with 5' vrna hook (238 kDa, Complex)
- Rna-dependent rna-polymerase l protein (235 kDa, Protein from SFTS virus AH12)
- Rna-dependent rna-polymerase l protein (Complex from SFTS virus AH12)
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*c)-3') (Complex from SFTS virus AH12)
Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION]
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8as7
Q-score: 0.582
Williams HM, Thorkelsson SR, Vogel D, Milewski M, Busch C, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2023) 51 pp. 1424-1442 [ Pubmed: 36651274 DOI: doi:10.1093/nar/gkac1249 ]
- Water (18 Da, Ligand)
- Sftsv l protein stalled at early elongation [early-elongation] (238 kDa, Complex)
- Rna (5'-r(p*ap*cp*a)-3') (Complex from SFTS virus AH12)
- Rna (5'-r(p*ap*cp*a)-3') (8 kDa, RNA from SFTS virus AH12)
- 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid (238 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*cp*up*up*up*gp*up*gp*u)-3') (Complex from SFTS virus AH12)
- Rna-dependent rna-polymerase l protein (235 kDa, Protein from SFTS virus AH12)
- 5'-o-[(s)-hydroxy{[(s)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine (483 Da, Ligand)
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*cp*ap*gp*a)-3') (Complex from SFTS virus AH12)
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*cp*ap*gp*a)-3') (6 kDa, RNA from SFTS virus AH12)
- Rna-dependent rna-polymerase l protein (Complex from SFTS virus AH12)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*cp*up*up*up*gp*up*gp*u)-3') (8 kDa, RNA from SFTS virus AH12)