Apo-structure of Lassa virus L protein (well-resolved polymerase core) [APO-CORE]
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7och
Q-score: 0.538
Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Gunther S, Grunewald K, Rosenthal M, Cusack S
Nat Commun (2021) 12 pp. 7018-7018 [ Pubmed: 34857749 DOI: doi:10.1038/s41467-021-27305-5 ]
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- Rna-directed rna polymerase l lassa mammarenavirus (253 kDa, Complex from Lassa mammarenavirus)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Apo-structure of Lassa virus L protein (well-resolved endonuclease) [APO-ENDO]
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7oe3
Q-score: 0.456
Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Gunther S, Grunewald K, Rosenthal M, Cusack S
Nat Commun (2021) 12 pp. 7018-7018 [ Pubmed: 34857749 DOI: doi:10.1038/s41467-021-27305-5 ]
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- Rna-directed rna polymerase l lassa mammarenavirus (253 kDa, Complex from Lassa mammarenavirus)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Apo-structure of Lassa virus L protein (well-resolved alpha ribbon) [APO-RIBBON]
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7oe7
Q-score: 0.314
Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Gunther S, Grunewald K, Rosenthal M, Cusack S
Nat Commun (2021) 12 pp. 7018-7018 [ Pubmed: 34857749 DOI: doi:10.1038/s41467-021-27305-5 ]
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- Rna-directed rna polymerase l lassa mammarenavirus (253 kDa, Complex from Lassa mammarenavirus)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Lassa virus L protein bound to 3' promoter RNA (well-resolved polymerase core) [3END-CORE]
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7oea
Q-score: 0.51
Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Gunther S, Grunewald K, Rosenthal M, Cusack S
Nat Commun (2021) 12 pp. 7018-7018 [ Pubmed: 34857749 DOI: doi:10.1038/s41467-021-27305-5 ]
- 3' vrna (5 kDa, RNA from Lassa mammarenavirus)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l lassa mammarenavirus (253 kDa, Complex from Lassa mammarenavirus)
Lassa virus L protein bound to 3' promoter RNA (well-resolved endonuclease) [3END-ENDO]
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 7oeb
Q-score: 0.506
Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Gunther S, Grunewald K, Rosenthal M, Cusack S
Nat Commun (2021) 12 pp. 7018-7018 [ Pubmed: 34857749 DOI: doi:10.1038/s41467-021-27305-5 ]
- 3' vrna (5 kDa, RNA from Lassa mammarenavirus)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l lassa mammarenavirus (253 kDa, Complex from Lassa mammarenavirus)
Lassa virus L protein with endonuclease and C-terminal domains in close proximity [MID-LINK]
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ojj
Q-score: 0.448
Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Gunther S, Grunewald K, Rosenthal M, Cusack S
Nat Commun (2021) 12 pp. 7018-7018 [ Pubmed: 34857749 DOI: doi:10.1038/s41467-021-27305-5 ]
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- Rna-directed rna polymerase l lassa mammarenavirus (253 kDa, Complex from Lassa mammarenavirus)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Lassa virus L protein bound to the distal promoter duplex [DISTAL-PROMOTER]
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 7ojk
Q-score: 0.374
Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Gunther S, Grunewald K, Rosenthal M, Cusack S
Nat Commun (2021) 12 pp. 7018-7018 [ Pubmed: 34857749 DOI: doi:10.1038/s41467-021-27305-5 ]
- 5' rna (3 kDa, RNA from Lassa mammarenavirus)
- Rna-directed rna polymerase l (Complex from Lassa mammarenavirus)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- 3' rna (2 kDa, RNA from Lassa mammarenavirus)
- Rna-directed rna polymerase l lassa mammarenavirus (253 kDa, Complex)
- Rna (Complex from Lassa mammarenavirus)
Lassa virus L protein in a pre-initiation conformation [PREINITIATION]
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ojl
Q-score: 0.494
Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Gunther S, Grunewald K, Rosenthal M, Cusack S
Nat Commun (2021) 12 pp. 7018-7018 [ Pubmed: 34857749 DOI: doi:10.1038/s41467-021-27305-5 ]
- Manganese (ii) ion (54 Da, Ligand)
- 5' rna (6 kDa, RNA from Lassa mammarenavirus)
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- 3' rna (6 kDa, RNA from Lassa mammarenavirus)
- Rna-directed rna polymerase l lassa mammarenavirus (253 kDa, Complex)
- Rna-directed rna polymerase l lassa mammarenavirus (Complex from Lassa mammarenavirus)
- Rna (Complex from Lassa mammarenavirus)
Lassa virus L protein in an elongation conformation [ELONGATION]
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 7ojn
Q-score: 0.531
Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Gunther S, Grunewald K, Rosenthal M, Cusack S
Nat Commun (2021) 12 pp. 7018-7018 [ Pubmed: 34857749 DOI: doi:10.1038/s41467-021-27305-5 ]
- Product rna (2 kDa, RNA from Lassa mammarenavirus)
- Manganese (ii) ion (54 Da, Ligand)
- Product rna (Complex from Lassa mammarenavirus)
- 5' rna (6 kDa, RNA from Lassa mammarenavirus)
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- Rna-directed rna polymerase l (Complex from Lassa mammarenavirus)
- Zinc ion (65 Da, Ligand)
- 5'-o-[(s)-hydroxy{[(s)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine (483 Da, Ligand)
- 3' rna (6 kDa, RNA from Lassa mammarenavirus)
- 5' rna, 3' rna (Complex from Lassa mammarenavirus)
- Rna-directed rna polymerase l lassa mammarenavirus (253 kDa, Complex)
Cryo-EM structure of a Phenuiviridae L protein
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 6y6k
Q-score: 0.522
Vogel D, Thorkelsson SR, Quemin ERJ, Meier K, Kouba T, Gogrefe N, Busch C, Reindl S, Gunther S, Cusack S, Grunewald K, Rosenthal M
Nucleic Acids Res (2020) 48 pp. 5749-5765 [ DOI: doi:10.1093/nar/gkaa253 Pubmed: 32313945 ]
- Severe fever with thrombocytopenia syndrome virus l protein (238 kDa, Complex from SFTS virus AH12)
- Magnesium ion (24 Da, Ligand)
- Rna-dependent rna polymerase (235 kDa, Protein from SFTS virus AH12)