Cryo-EM structure of compound 9n bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8jhy
Q-score: 0.538
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- 7-methyl-n-[(2r)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide (428 Da, Ligand)
- Hca2 in complex with gi heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8jii
Q-score: 0.521
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- 7-methyl-n-[(2r)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide (428 Da, Ligand)
- Nicotinic acid (123 Da, Ligand)
- Hca2 in complex with gi heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of niacin bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8jil
Q-score: 0.476
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Nicotinic acid (123 Da, Ligand)
- Scfv16 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Niacin-bound hcar2 in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8jim
Q-score: 0.509
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Hca2 in complex with gi heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- (2z)-4-methoxy-4-oxobut-2-enoic acid (130 Da, Ligand)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7y64
Q-score: 0.498
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ Pubmed: 36806352 DOI: doi:10.1038/s41422-023-00779-2 ]
- C5a-bound c5ar1 (Complex from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)
- C5a-bound c5ar1 in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7y65
Q-score: 0.438
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ Pubmed: 36806352 DOI: doi:10.1038/s41422-023-00779-2 ]
- C5apep-bound c5ar1 in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C5apep peptide (869 Da, Protein from synthetic construct)
- Scfv16 (Complex from Mus musculus)
- C5apep-bound c5ar1 (Complex from Homo sapiens)
- Gi heterotrimer (Complex from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7y66
Q-score: 0.478
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ Pubmed: 36806352 DOI: doi:10.1038/s41422-023-00779-2 ]
- Bm213-bound c5ar1 in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Bm213-bound c5ar1 (Complex from Homo sapiens)
- Bm213 peptide (901 Da, Protein from synthetic construct)
- Scfv16 (Complex from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7y67
Q-score: 0.494
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ Pubmed: 36806352 DOI: doi:10.1038/s41422-023-00779-2 ]
- C089-bound c5ar1 (Complex from Homo sapiens)
- C089-bound c5ar1-i116a in complex with gi heterotrimer (Complex)
- C089 peptide (902 Da, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)