Cryo-EM structure of CB2-G protein complex
Yang X, Zhou P, Shen S, Hu Q, Tian C, Xia A, Wang Y, Yang Z, Nan J, Zhou Y, Chen S, Tian X, Wu C, Lin G, Zhang L, Wang K, Zheng T, Zou J, Yan W, Shao Z, Yang S
PNAS (2024) 121 pp. e2401091121-e2401091121 [ DOI: doi:10.1073/pnas.2401091121 Pubmed: 39024109 ]
- Yl025-bound cb2r in complex with gi heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- 4-[3-(4-fluoranyl-2~{h}-indazol-7-yl)-1,2,4-oxadiazol-5-yl]-1-(4-fluorophenyl)azepan-2-one (409 Da, Ligand)
- Cb2r-gi (Complex from Homo sapiens)
- Cannabinoid receptor 2 (35 kDa, Protein from Homo sapiens)
Paltusotine-bound SSTR2-Gi complex
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7yac
Q-score: 0.477
Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z
Nat Commun (2023) 14 pp. 962-962 [ DOI: doi:10.1038/s41467-023-36673-z Pubmed: 36810324 ]
- Somatostatin receptor type 2 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Paltusotine-bound somatostatin receptor 2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Scfv16 (Complex)
- Paltusotine (456 Da, Ligand)
- Guanine nucleotide-binding protein, somatostatin receptor 2 (Complex from Mus musculus)
Octreotide-bound SSTR2-Gi complex
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 7yae
Q-score: 0.382
Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z
Nat Commun (2023) 14 pp. 962-962 [ DOI: doi:10.1038/s41467-023-36673-z Pubmed: 36810324 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Octreotide-bound somatostatin receptor 2 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Dpn-cys-phe-dtr-lys-thr-cys-tho (Complex)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Somatostatin receptor type 2 (42 kDa, Protein from Homo sapiens)
- Octreotide-bound somatostatin receptor 2 (Complex from Homo sapiens)
- Dpn-cys-phe-dtr-lys-thr-cys-tho (1 kDa, Protein from synthetic construct)