Human TOM complex with whole Tom20
Resolution: 5.92 Å
EM Method: Single-particle
Fitted PDBs: 8xva
Q-score: 0.225
Su J, Tian X, Wang Z, Yang J, Sun S, Sui SF
Pnas Nexus (2024) 3 pp. pgae269-pgae269 [ DOI: doi:10.1093/pnasnexus/pgae269 Pubmed: 39071881 ]
- Mitochondrial import receptor subunit tom5 homolog (6 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom6 homolog (8 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom40 homolog (37 kDa, Protein from Homo sapiens)
- Tom complex with whole tom20 (168 MDa, Complex from Homo sapiens)
- Mitochondrial import receptor subunit tom22 homolog (15 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom20 homolog (16 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom7 homolog (6 kDa, Protein from Homo sapiens)
3-Methylcrotonyl-CoA Carboxylase in MCCD state with Acetyl CoA
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Dodecamer of human mcc (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state with MCoA
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8jxm
Q-score: 0.289
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Dodecamer of human mcc (Complex from Homo sapiens)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with MCoA
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jxn
Q-score: 0.382
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ Pubmed: 39223421 DOI: doi:10.1038/s41594-024-01379-3 ]
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Dodecamer of human mcc (Complex from Homo sapiens)
Cryo-EM structure of human receptor with G proteins
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ikg
Q-score: 0.432
Shen S, Wu C, Lin G, Yang X, Zhou Y, Zhao C, Miao Z, Tian X, Wang K, Yang Z, Liu Z, Guo N, Li Y, Xia A, Zhou P, Liu J, Yan W, Ke B, Yang S, Shao Z
PNAS (2024) 121 pp. e2321532121-e2321532121 [ DOI: doi:10.1073/pnas.2321532121 Pubmed: 38830102 ]
- Cb02-bound cb1r in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 3-[(1s)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1h-indole (332 Da, Ligand)
- Cannabinoid receptor 1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- Cannabinoid receptor 1 (35 kDa, Protein from Homo sapiens)
Cryo-EM structure of human receptor with G proteins
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ikh
Q-score: 0.431
Shen S, Wu C, Lin G, Yang X, Zhou Y, Zhao C, Miao Z, Tian X, Wang K, Yang Z, Liu Z, Guo N, Li Y, Xia A, Zhou P, Liu J, Yan W, Ke B, Yang S, Shao Z
PNAS (2024) 121 pp. e2321532121-e2321532121 [ DOI: doi:10.1073/pnas.2321532121 Pubmed: 38830102 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 3-[(1r)-1-(2-methoxyphenyl)-2-nitro-ethyl]-2-phenyl-1h-indole (372 Da, Ligand)
- Cb05-bound cb1r in complex with gi heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- Cannabinoid receptor 1 (35 kDa, Protein from Homo sapiens)
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8jaw
Q-score: 0.506
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ Pubmed: 39223421 DOI: doi:10.1038/s41594-024-01379-3 ]
- Dodecamer of human mcc (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j7d
Q-score: 0.435
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Human mcc (Complex from Homo sapiens)
Cryo-EM structure of the gasdermin pore from Trichoplax adhaerens