Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7uja
Q-score: 0.492
Che Y, Gribenko AV, Song X, Handke LD, Efferen KS, Tompkins K, Kodali S, Nunez L, Prasad AK, Phelan LM, Ammirati M, Yu X, Lees JA, Chen W, Martinez L, Roopchand V, Han S, Qiu X, DeVincenzo JP, Jansen KU, Dormitzer PR, Swanson KA
Sci Transl Med (2023) 15 pp. eade6422-eade6422 [ Pubmed: 37023209 DOI: doi:10.1126/scitranslmed.ade6422 ]
- Am14 fab heavy chain (26 kDa, Protein from Mus musculus)
- Human respiratory syncytial virus f variant (construct pxcs847a) with fabs am14 and am22 (Complex from Respiratory syncytial virus)
- Rsv variant (construct pxcs847a) f2 (12 kDa, Protein from Respiratory syncytial virus)
- Am22 fab light chain (23 kDa, Protein from Mus musculus)
- Am22 fab heavy chain (25 kDa, Protein from Mus musculus)
- Rsv variant (construct pxcs847a) f1 (45 kDa, Protein from Respiratory syncytial virus)
- Am14 fab light chain (23 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7l7f
Q-score: 0.517
Vogel AB, Kanevsky I, Che Y, Swanson KA, Muik A, Vormehr M, Kranz LM, Walzer KC, Hein S, Guler A, Loschko J, Maddur MS, Ota-Setlik A, Tompkins K, Cole J, Lui BG, Ziegenhals T, Plaschke A, Eisel D, Dany SC, Fesser S, Erbar S, Bates F, Schneider D, Jesionek B, Sanger B, Wallisch AK, Feuchter Y, Junginger H, Krumm SA, Heinen AP, Adams-Quack P, Schlereth J, Schille S, Kroner C, de la Caridad Guimil Garcia R, Hiller T, Fischer L, Sellers RS, Choudhary S, Gonzalez O, Vascotto F, Gutman MR, Fontenot JA, Hall-Ursone S, Brasky K, Griffor MC, Han S, Su AAH, Lees JA, Nedoma NL, Mashalidis EH, Sahasrabudhe PV, Tan CY, Pavliakova D, Singh G, Fontes-Garfias C, Pride M, Scully IL, Ciolino T, Obregon J, Gazi M, Carrion Jr R, Alfson KJ, Kalina WV, Kaushal D, Shi PY, Klamp T, Rosenbaum C, Kuhn AN, Tureci O, Dormitzer PR, Jansen KU, Sahin U
Nature (2021) 592 pp. 283-289 [ Pubmed: 33524990 DOI: doi:10.1038/s41586-021-03275-y ]
- Spike glycoprotein, envelope glycoprotein fusion (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (Complex from Homo sapiens)
- Spike glycoprotein, envelope glycoprotein fusion (29 kDa, Protein from Human immunodeficiency virus 1)
- Human ace2 receptor complexed with protein encoded by vaccine candidate bnt162b1 (Complex)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
Cryo-EM structure of protein encoded by vaccine candidate BNT162b2
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7l7k
Q-score: 0.484
Vogel AB, Kanevsky I, Che Y, Swanson KA, Muik A, Vormehr M, Kranz LM, Walzer KC, Hein S, Guler A, Loschko J, Maddur MS, Ota-Setlik A, Tompkins K, Cole J, Lui BG, Ziegenhals T, Plaschke A, Eisel D, Dany SC, Fesser S, Erbar S, Bates F, Schneider D, Jesionek B, Sanger B, Wallisch AK, Feuchter Y, Junginger H, Krumm SA, Heinen AP, Adams-Quack P, Schlereth J, Schille S, Kroner C, de la Caridad Guimil Garcia R, Hiller T, Fischer L, Sellers RS, Choudhary S, Gonzalez O, Vascotto F, Gutman MR, Fontenot JA, Hall-Ursone S, Brasky K, Griffor MC, Han S, Su AAH, Lees JA, Nedoma NL, Mashalidis EH, Sahasrabudhe PV, Tan CY, Pavliakova D, Singh G, Fontes-Garfias C, Pride M, Scully IL, Ciolino T, Obregon J, Gazi M, Carrion Jr R, Alfson KJ, Kalina WV, Kaushal D, Shi PY, Klamp T, Rosenbaum C, Kuhn AN, Tureci O, Dormitzer PR, Jansen KU, Sahin U
Nature (2021) 592 pp. 283-289 [ Pubmed: 33524990 DOI: doi:10.1038/s41586-021-03275-y ]