human LonP1, R-state, incubated in AMPPCP
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7oxo
Q-score: 0.298
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ Pubmed: 35870450 DOI: doi:10.1016/j.str.2022.06.006 ]
- Lon protease homolog, mitochondrial (106 kDa, Protein from Homo sapiens)
- Human mitochondrial lon protease homolog (639 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7ngf
Q-score: 0.206
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ DOI: doi:10.1016/j.str.2022.06.006 Pubmed: 35870450 ]
- Substrate protein chain:g (4 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- P2c-state of lonp1 hexameric complex in presence of atp/adp and bound endogenous substrate protein (600 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (93 kDa, Protein from Homo sapiens)
R-state of wild type human mitochondrial LONP1 protease bound to endogenous ADP
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7ngl
Q-score: 0.281
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ DOI: doi:10.1016/j.str.2022.06.006 Pubmed: 35870450 ]
- Quaternary structure of human lonp1 (Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
D1-state of wild type human mitochondrial LONP1 protease
Resolution: 15.0 Å
EM Method: Single-particle
Fitted PDBs: 7ngp
Q-score: 0.065
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ DOI: doi:10.1016/j.str.2022.06.006 Pubmed: 35870450 ]
- D1-state of lonp1 hexameric complex (600 kDa, Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Human mitochondrial Lon protease homolog, D2-state
Resolution: 12.0 Å
EM Method: Single-particle
Fitted PDBs: 7ngq
Q-score: 0.078
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ DOI: doi:10.1016/j.str.2022.06.006 Pubmed: 35870450 ]
- Lon protease homolog, mitochondrial (Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Resolution: 7.5 Å
EM Method: Single-particle
Fitted PDBs: 7ngc
Q-score: 0.145
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ DOI: doi:10.1016/j.str.2022.06.006 Pubmed: 35870450 ]
- P2a-state of lonp1 hexameric complex in presence of atpgs and bound substrate protein (600 kDa, Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (96 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Substrate protein (4 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
P1a-state of wild type human mitochondrial LONP1 protease with bound substrate protein and ATPgS
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7nfy
Q-score: 0.335
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ DOI: doi:10.1016/j.str.2022.06.006 Pubmed: 35870450 ]
- Lon protease homolog, mitochondrial (96 kDa, Protein from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Substrate protein (4 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- P1a-state of lonp1 hexameric complex with atpgs and bound substrate protein (600 kDa, Complex from Homo sapiens)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7ng4
Q-score: 0.252
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ DOI: doi:10.1016/j.str.2022.06.006 Pubmed: 35870450 ]
- P1b-state of hexameric lonp1 complex with atp/adp and bound endogenous substrate protein (600 kDa, Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (96 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Substrate protein, chain g (4 kDa, Protein from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7ng5
Q-score: 0.348
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ DOI: doi:10.1016/j.str.2022.06.006 Pubmed: 35870450 ]
- P1c-state of hexameric lonp1 complex with atp/adp and bound endogenous substrate protein (600 kDa, Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (96 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Substrate protein chain:g (4 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)