The pore conformation of lymphocyte perforin
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7pag
Q-score: 0.297
Ivanova ME, Lukoyanova N, Malhotra S, Topf M, Trapani JA, Voskoboinik I, Saibil HR
Sci Adv (2022) 8 pp. eabk3147-eabk3147 [ DOI: doi:10.1126/sciadv.abk3147 Pubmed: 35148176 ]
- Perforin-1 (60 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Oligomerised mouse perforin in its inserted state (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Membrane embedded pleurotolysin pore with 13 fold symmetry
Resolution: 11.0 Å
EM Method: Single-particle
Fitted PDBs: 4v2t
Q-score: 0.079
Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA
PLoS Biol (2015) 13 pp. e1002049-e1002049 [ DOI: doi:10.1371/journal.pbio.1002049 Pubmed: 25654333 ]
- Pleurotolysin b (52 kDa, Protein from Pleurotus ostreatus)
- Pleurotolysin pore in liposomes (Sample)
- Pleurotolysin a (17 kDa, Protein from Pleurotus ostreatus)
Membrane bound pleurotolysin prepore (TMH1 lock) trapped with engineered disulphide cross-link
Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA
PLoS Biol (2015) 13 pp. e1002049-e1002049 [ DOI: doi:10.1371/journal.pbio.1002049 Pubmed: 25654333 ]
Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link
Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA
PLoS Biol (2015) 13 pp. e1002049-e1002049 [ DOI: doi:10.1371/journal.pbio.1002049 Pubmed: 25654333 ]
Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA
PLoS Biol (2015) 13 pp. e1002049-e1002049 [ DOI: doi:10.1371/journal.pbio.1002049 Pubmed: 25654333 ]
Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC
Nature (2010) 468 pp. 447-451 [ DOI: doi:10.1038/nature09518 Pubmed: 21037563 ]
Perforin monomer, conformation 1
Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC
Nature (2010) 468 pp. 447-451 [ DOI: doi:10.1038/nature09518 Pubmed: 21037563 ]
- Perforin (67 kDa, Sample)
- Perforin (67 kDa, Protein from Mus musculus)
Perforin monomer, conformation 2
Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC
Nature (2010) 468 pp. 447-451 [ DOI: doi:10.1038/nature09518 Pubmed: 21037563 ]
- Perforin (67 kDa, Sample)
- Perforin (67 kDa, Protein from Mus musculus)