Structure of the HER4/NRG1b Homodimer Extracellular Domain
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8u4i
Q-score: 0.388
Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
eLife (2024) 12 [ Pubmed: 38498590 DOI: doi:10.7554/eLife.92873 ]
- Receptor tyrosine-protein kinase erbb-4 (68 kDa, Protein from Homo sapiens)
- Her4/nrg1b homodimer (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (5 kDa, Protein from Homo sapiens)
Structure of the HER4/BTC Homodimer Extracellular Domain
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8u4j
Q-score: 0.359
Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
eLife (2024) 12 [ Pubmed: 38498590 DOI: doi:10.7554/eLife.92873 ]
- Receptor tyrosine-protein kinase erbb-4 (68 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Betacellulin (5 kDa, Protein from Homo sapiens)
- Her4/btc homodimer (306 kDa, Complex from Homo sapiens)
Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain
Resolution: 4.27 Å
EM Method: Single-particle
Fitted PDBs: 8u4k
Q-score: 0.284
Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
eLife (2024) 12 [ Pubmed: 38498590 DOI: doi:10.7554/eLife.92873 ]
- Ternary complex of her2/her4/btc (284 kDa, Complex from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (66 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Betacellulin (5 kDa, Protein from Homo sapiens)
- Isoform jm-a cyt-1 of receptor tyrosine-protein kinase erbb-4 (67 kDa, Protein from Homo sapiens)
Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8u4l
Q-score: 0.423
Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
eLife (2024) 12 [ Pubmed: 38498590 DOI: doi:10.7554/eLife.92873 ]
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (5 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (66 kDa, Protein from Homo sapiens)
- Ternary complex of her2/her4/nrg1b (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform jm-a cyt-1 of receptor tyrosine-protein kinase erbb-4 (67 kDa, Protein from Homo sapiens)
Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7mn8
Q-score: 0.342
Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
Nature (2021) 600 pp. 339-343 [ Pubmed: 34759323 DOI: doi:10.1038/s41586-021-04084-z ]
- Her3 (Complex from Homo sapiens)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (9 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-3 (117 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neuregulin-1b isoform 6 (Complex from Homo sapiens)
- Nrg1b-bound her2/her3 heterodimer bound to the trastuzumab fab in the context of near full-length receptors (Complex)
- Trastuzumab (herceptin) fab (Complex from Homo sapiens)
- Trastuzumab fab heavy chain (25 kDa, Protein from Homo sapiens)
- Her2-s310f-mbp fusion (Complex from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2,maltose/maltodextrin-binding periplasmic protein (160 kDa, Protein from Escherichia coli)
- Trastuzumab fab light chain (24 kDa, Protein from Homo sapiens)
The HER2/HER3/NRG1b Heterodimer
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7mn5
Q-score: 0.454
Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
Nature (2021) 600 pp. 339-343 [ Pubmed: 34759323 DOI: doi:10.1038/s41586-021-04084-z ]
- Her2/her3/nrg1b heterocomplex in the context of near full-length receptors (Complex)
- Neuregulin-1 (Complex from Homo sapiens)
- Her3 (Complex from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-3 (117 kDa, Protein from Homo sapiens)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (9 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2,maltose/maltodextrin-binding periplasmic protein (160 kDa, Protein from Escherichia coli)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Her2-mbp fusion (Complex from Homo sapiens)
The HER2 S310F/HER3/NRG1b Heterodimer
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7mn6
Q-score: 0.453
Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
Nature (2021) 600 pp. 339-343 [ Pubmed: 34759323 DOI: doi:10.1038/s41586-021-04084-z ]
- Her3 (Complex from Homo sapiens)
- Nrb1b-bound her2-s310f/her3 heterodimer in the context of near full-length receptors (Complex)
- Neuregulin-1 (Complex from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-3 (117 kDa, Protein from Homo sapiens)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (9 kDa, Protein from Homo sapiens)
- Her2-s310f, mbp fusion (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Receptor tyrosine-protein kinase erbb-2,maltose/maltodextrin-binding periplasmic protein (160 kDa, Protein from Escherichia coli)
Human Tom70 in complex with SARS CoV2 Orf9b
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7kdt
Q-score: 0.473
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Science (2020) 370 [ DOI: doi:10.1126/science.abe9403 Pubmed: 33060197 ]
- Orf9b-tom70 complex (Complex from Homo sapiens)
- Orf9b protein (10 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Mitochondrial import receptor subunit tom70 (56 kDa, Protein from Homo sapiens)