Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7mn8
Q-score: 0.342
Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
Nature (2021) 600 pp. 339-343 [ DOI: doi:10.1038/s41586-021-04084-z Pubmed: 34759323 ]
- Her2-s310f-mbp fusion (Complex from Homo sapiens)
- Nrg1b-bound her2/her3 heterodimer bound to the trastuzumab fab in the context of near full-length receptors (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Her3 (Complex from Homo sapiens)
- Neuregulin-1b isoform 6 (Complex from Homo sapiens)
- Trastuzumab fab heavy chain (25 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-3 (117 kDa, Protein from Homo sapiens)
- Trastuzumab (herceptin) fab (Complex from Homo sapiens)
- Trastuzumab fab light chain (24 kDa, Protein from Homo sapiens)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (9 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2,maltose/maltodextrin-binding periplasmic protein (160 kDa, Protein from Escherichia coli)
The HER2/HER3/NRG1b Heterodimer
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7mn5
Q-score: 0.454
Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
Nature (2021) 600 pp. 339-343 [ Pubmed: 34759323 DOI: doi:10.1038/s41586-021-04084-z ]
- Her3 (Complex from Homo sapiens)
- Her2/her3/nrg1b heterocomplex in the context of near full-length receptors (Complex)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (9 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-3 (117 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Her2-mbp fusion (Complex from Homo sapiens)
- Neuregulin-1 (Complex from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2,maltose/maltodextrin-binding periplasmic protein (160 kDa, Protein from Escherichia coli)
The HER2 S310F/HER3/NRG1b Heterodimer
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7mn6
Q-score: 0.453
Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
Nature (2021) 600 pp. 339-343 [ Pubmed: 34759323 DOI: doi:10.1038/s41586-021-04084-z ]
- Nrb1b-bound her2-s310f/her3 heterodimer in the context of near full-length receptors (Complex)
- Her3 (Complex from Homo sapiens)
- Her2-s310f, mbp fusion (Complex from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2,maltose/maltodextrin-binding periplasmic protein (160 kDa, Protein from Escherichia coli)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (9 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-3 (117 kDa, Protein from Homo sapiens)
- Neuregulin-1 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)