GC-C-Hsp90-Cdc37 regulatory complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8fx4
Q-score: 0.329
Caveney NA, Tsutsumi N, Garcia KC
eLife (2023) 12 [ Pubmed: 37535399 DOI: doi:10.7554/eLife.86784 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Heat shock protein hsp 90-beta (83 kDa, Protein from Cricetulus griseus)
- Guanylyl cyclase c (85 kDa, Protein from Homo sapiens)
- Gc-c-hsp90-cdc37 regulatory complex (Complex)
- Hsp90 co-chaperone cdc37 (44 kDa, Protein from Cricetulus griseus)
Extracellular architecture of an engineered canonical Wnt signaling ternary complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8ctg
Q-score: 0.109
Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude KM, Wang N, Miao Y, Glassman CR, Caveney NA, Janda CY, Hannoush RN, Garcia KC
PNAS (2023) 120 pp. e2218238120-e2218238120 [ DOI: doi:10.1073/pnas.2218238120 Pubmed: 36893265 ]
- Haxwnt8-mfzd8crd-hlrp6e1e2 (130 kDa, Complex)
- Frizzled-8 (Complex from Mus musculus)
- Frizzled-8 (15 kDa, Protein from Mus musculus)
- Low-density lipoprotein receptor-related protein 6 (73 kDa, Protein from Homo sapiens)
- Palmitoleic acid (254 Da, Ligand)
- Protein wnt-8 (36 kDa, Protein from Xenopus laevis)
- Low-density lipoprotein receptor-related protein 6 (Complex from Homo sapiens)
- Protein wnt-8 (Complex from Xenopus laevis)
Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Resolution: 5.5 Å
EM Method: Single-particle
Fitted PDBs: 8ewy
Q-score: 0.296
Caveney NA, Saxton RA, Waghray D, Glassman CR, Tsutsumi N, Hubbard SR, Garcia KC
Cell Rep (2023) 42 pp. 112201-112201 [ Pubmed: 36867534 DOI: doi:10.1016/j.celrep.2023.112201 ]
- Interferon lambda receptor 1 (9 kDa, Protein from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Structure of janus kinase (jak) dimer complexed with cytokine receptor intracellular domain (Complex from Mus musculus)
- Tyrosine-protein kinase (136 kDa, Protein from Mus musculus)
- Adenosine (267 Da, Ligand)
Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7t6f
Q-score: 0.457
Glassman CR, Tsutsumi N, Saxton RA, Lupardus PJ, Jude KM, Garcia KC
Science (2022) 376 pp. 163-169 [ DOI: doi:10.1126/science.abn8933 Pubmed: 35271300 ]
- Interferon lambda receptor 1 (9 kDa, Protein from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Tyrosine-protein kinase (136 kDa, Protein from Mus musculus)
- Adenosine (267 Da, Ligand)
- Gcn4-zippered dimeric ifn-lambda intracellular domain bound to two jak1s (290 kDa, Complex from Mus musculus)
Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7rkf
Q-score: 0.44
Tsutsumi N, Maeda S, Qu Q, Voegele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC
Sci Adv (2022) 8 pp. eabl5442- [ DOI: doi:10.1126/sciadv.abl5442 ]
- G11in18 heterotrimer (90 kDa, Complex from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Fractalkine (10 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cx3cl1-us28 (50 kDa, Complex from Human betaherpesvirus 5)
- G-protein coupled receptor homolog us28 (42 kDa, Protein from Human cytomegalovirus)
- Guanine nucleotide-binding protein subunit alpha-11 (41 kDa, Protein from Homo sapiens)
- Cx3cl1-us28-g11in18-scfv16 complex (Complex)
- Scfv16 (30 kDa, Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
Structure of CX3CL1-US28-Gi-scFv16 in C-state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7rkm
Q-score: 0.477
Tsutsumi N, Maeda S, Qu Q, Voegele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC
Sci Adv (2022) 8 pp. eabl5442- [ DOI: doi:10.1126/sciadv.abl5442 ]
- Fractalkine (10 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cx3cl1-us28 (50 kDa, Complex from Human betaherpesvirus 5)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv16 (30 kDa, Complex from Mus musculus)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
- Gi heterotrimer (90 kDa, Complex from Homo sapiens)
- Cx3cl1-us28-gi-scfv16 complex (Complex)
- G-protein coupled receptor homolog us28 (42 kDa, Protein from Human betaherpesvirus 5)
Binding mode of US27-Gi-scFv16 in OCL-state
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7rky
Q-score: 0.43
Tsutsumi N, Maeda S, Qu Q, Voegele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC
Sci Adv (2022) 8 pp. eabl5442- [ DOI: doi:10.1126/sciadv.abl5442 ]
- Gi heterotrimer (90 kDa, Complex from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Us27-gi-scfv16 complex (Complex)
- G-protein coupled receptor homolog us27 (44 kDa, Protein from Human cytomegalovirus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Complex from Mus musculus)
- Us27 (40 kDa, Complex from Human betaherpesvirus 5)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)