Structure of signaling thrombopoietin-MPL receptor complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8g04
Q-score: 0.44
Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC
Cell (2023) 186 pp. 4189-4203.e22 [ Pubmed: 37633268 DOI: doi:10.1016/j.cell.2023.07.037 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Thrombopoietin receptor (71 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Thrombopoietin signaling complex with two thrombopoietin receptor chains (160 kDa, Complex from Homo sapiens)
- Thrombopoietin (18 kDa, Protein from Homo sapiens)
GC-C-Hsp90-Cdc37 regulatory complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8fx4
Q-score: 0.329
Caveney NA, Tsutsumi N, Garcia KC
eLife (2023) 12 [ Pubmed: 37535399 DOI: doi:10.7554/eLife.86784 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Heat shock protein hsp 90-beta (83 kDa, Protein from Cricetulus griseus)
- Guanylyl cyclase c (85 kDa, Protein from Homo sapiens)
- Gc-c-hsp90-cdc37 regulatory complex (Complex)
- Hsp90 co-chaperone cdc37 (44 kDa, Protein from Cricetulus griseus)
Extracellular architecture of an engineered canonical Wnt signaling ternary complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8ctg
Q-score: 0.109
Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude KM, Wang N, Miao Y, Glassman CR, Caveney NA, Janda CY, Hannoush RN, Garcia KC
PNAS (2023) 120 pp. e2218238120-e2218238120 [ DOI: doi:10.1073/pnas.2218238120 Pubmed: 36893265 ]
- Haxwnt8-mfzd8crd-hlrp6e1e2 (130 kDa, Complex)
- Frizzled-8 (Complex from Mus musculus)
- Frizzled-8 (15 kDa, Protein from Mus musculus)
- Low-density lipoprotein receptor-related protein 6 (73 kDa, Protein from Homo sapiens)
- Palmitoleic acid (254 Da, Ligand)
- Protein wnt-8 (36 kDa, Protein from Xenopus laevis)
- Low-density lipoprotein receptor-related protein 6 (Complex from Homo sapiens)
- Protein wnt-8 (Complex from Xenopus laevis)
Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Resolution: 5.5 Å
EM Method: Single-particle
Fitted PDBs: 8ewy
Q-score: 0.296
Caveney NA, Saxton RA, Waghray D, Glassman CR, Tsutsumi N, Hubbard SR, Garcia KC
Cell Rep (2023) 42 pp. 112201-112201 [ Pubmed: 36867534 DOI: doi:10.1016/j.celrep.2023.112201 ]
- Interferon lambda receptor 1 (9 kDa, Protein from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Structure of janus kinase (jak) dimer complexed with cytokine receptor intracellular domain (Complex from Mus musculus)
- Tyrosine-protein kinase (136 kDa, Protein from Mus musculus)
- Adenosine (267 Da, Ligand)
Structure of the homodimeric IL-25-IL-17RB binary complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7uwj
Q-score: 0.316
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Interleukin-25 (21 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-17 receptor b (28 kDa, Protein from Homo sapiens)
- Homodimeric il-25-il-17rb binary complex (Complex from Homo sapiens)
Structure of the higher-order IL-25-IL-17RB complex
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7uwk
Q-score: 0.165
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Higher-order il-25-il-17rb complex (Complex from Homo sapiens)
- Interleukin-25 (21 kDa, Protein from Homo sapiens)
- Interleukin-17 receptor b (33 kDa, Protein from Homo sapiens)
Structure of the IL-25-IL-17RB-IL-17RA ternary complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7uwl
Q-score: 0.269
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Interleukin-25 (21 kDa, Protein from Homo sapiens)
- Interleukin-17 receptor b (33 kDa, Protein from Homo sapiens)
- Ternary il-25-il-17rb-il-17ra complex (Complex from Homo sapiens)
- Interleukin-17 receptor a (36 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the IL-17A-IL-17RA binary complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7uwm
Q-score: 0.536
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Interleukin-17 receptor a (31 kDa, Protein from Homo sapiens)
- Interleukin-17a (19 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Il-17a-il-17ra binary complex (Complex from Homo sapiens)
Structure of the IL-17A-IL-17RA-IL-17RC ternary complex
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 7uwn
Q-score: 0.316
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Isoform 5 of interleukin-17 receptor c (53 kDa, Protein from Homo sapiens)
- Interleukin-17a (19 kDa, Protein from Homo sapiens)
- Il-17a-il-17ra-il-17rc ternary complex (Complex from Homo sapiens)
- Interleukin-17 receptor a (36 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
IL-27 quaternary receptor signaling complex
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 7u7n
Q-score: 0.36
Caveney NA, Glassman CR, Jude KM, Tsutsumi N, Garcia KC
eLife (2022) 11 [ Pubmed: 35579417 DOI: doi:10.7554/eLife.78463 ]
- Il-27 quaternary receptor signaling complex (Complex from Homo sapiens)
- Interleukin-27 subunit alpha (24 kDa, Protein from Homo sapiens)
- Interleukin-27 subunit beta (23 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (34 kDa, Protein from Homo sapiens)
- Interleukin-27 receptor subunit alpha (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)